ArticleScientific reports2018
Absolute Configurations of 14,15-Hydroxylated Prenylxanthones from a Marine-Derived Aspergillus sp. Fungus by Chiroptical Methods.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Cytotoxic Compounds from Marine Fungi: Sources, Structures, and Bioactivity.Marine drugs · 2024Review
- Marine-Derived Xanthone from 2010 to 2021: Isolation, Bioactivities and Total Synthesis.Marine drugs · 2022Review
- Bioactive Marine Xanthones: A Review.Marine drugs · 2022Review
- Structure Revision and Protein Tyrosine Phosphatase Inhibitory Activity of Drazepinone.Marine drugs · 2021Article
- A Review on Microbial Products and Their Perspective Application as Antimicrobial Agents.Biomolecules · 2021Review
- Recent updates on the bioactive compounds of the marine-derived genusRSC advances · 2021Review
- Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies.Marine drugs · 2021Review
- Absolute Configurations and Chitinase Inhibitions of Quinazoline-Containing Diketopiperazines from the Marine-Derived FungusMarine drugs · 2020Article
- Antibiotics from Extremophilic Micromycetes.Russian journal of bioorganic chemistry · 2020Article
- Asperienes A-D, Bioactive Sesquiterpenes from the Marine-Derived FungusMarine drugs · 2019Article
- Article
- Structures and Absolute Configurations of Diketopiperazine Alkaloids Chrysopiperazines A⁻C from the Gorgonian-DerivedMarine drugs · 2019Article
- Benzophenone Derivatives from an Algal-Endophytic Isolate of Penicillium chrysogenum and Their Cytotoxicity.Molecules (Basel, Switzerland) · 2018Article
- Phytotoxicity and anti-phytopathogenic activities of marine-derived fungi and their secondary metabolites.RSC advances · 2018Article
- Aspergixanthones I⁻K, New Anti-Marine drugs · 2018Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determination of the absolute configrations for natural products is one of the most important and challenging tasks, especially when the molecules display high conformational flexibility. In this paper, eight new prenylxanthones, aspergixanthones A-H (1-8), and one known analogue (9), were isolated from the marine-derived fungus Aspergillus sp. ZA-01. The absolute configurations of C-14 and C-15 in 1-8 were difficult to be assigned due to the high conformational flexibility of the chains. To solve this problem, the experimental ECD, ORD, and VCD spectra of 1 were combined for analysis with the corresponding theoretical predictions for its different diastereomers. This study suggested that a concerted application of more than one chiroptical methods could be used as a preferable approach for the stereochemical characterizations of flexible molecules. Compounds 1-9 were evaluated for their cytotoxic and antibacterial activities. Among them, 6 showed cytotoxicity against the A-549 cell line with the IC
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