ArticleScientific reports2018
Carbohydrate Syntrophy enhances the establishment of Bifidobacterium breve UCC2003 in the neonatal gut.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Sequence-Based and Functional Analysis for the Discovery of N-Glycan Degrading Glycosidases From the Microbial Metagenome of the Infant Gut.MicrobiologyOpen · 2026Article
- FUT2-mediated intestinal fucosylation: a master regulator of host-microbiota symbiosis in health and disease.Frontiers in microbiology · 2026Review
- NMR-Based Metabolomic Profiling Highlights Functional Nutritional Gaps Between Human Milk, Infant Formulas, and Animal Milks.Metabolites · 2025Article
- Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants.Nature communications · 2025Article
- Development of an infant colon simulatingMicrobiology spectrum · 2024Article
- Cross-feeding of bifidobacteria promotes intestinal homeostasis: a lifelong perspective on the host health.NPJ biofilms and microbiomes · 2024Review
- Resource sharing of an infant gut microbiota synthetic community in combinations of human milk oligosaccharides.The ISME journal · 2024Article
- Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria.FEMS microbiology reviews · 2023Review
- Quantitative Physiology and Proteome Adaptations of Bifidobacterium breve NRBB57 at Near-Zero Growth Rates.Microbiology spectrum · 2023Article
- Fungal β-glucan-facilitated cross-feeding activities between Bacteroides and Bifidobacterium species.Communications biology · 2023Article
- Journey of the Probiotic Bacteria: Survival of the Fittest.Microorganisms · 2022Review
- Transcriptional Changes in Bifidobacterium bifidum Involved in Synergistic Multispecies Biofilms.Microbial ecology · 2022Article
- Human milk oligosaccharide-sharing by a consortium of infant derived Bifidobacterium species.Scientific reports · 2022Article
- Critical roles of a housekeeping sortase of probioticiScience · 2021Article
- Architecture Insight of Bifidobacterial α-L-Fucosidases.International journal of molecular sciences · 2021Article
- A Resource for Cloning and Expression Vectors Designed for Bifidobacteria: Overview of Available Tools and Biotechnological Applications.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Biochemical analysis of cross-feeding behaviour between two common gut commensals when cultivated on plant-derived arabinogalactan.Microbial biotechnology · 2020Article
- Ecological Importance of Cross-Feeding of the Intermediate Metabolite 1,2-Propanediol between Bacterial Gut Symbionts.Applied and environmental microbiology · 2020Article
- Enzymatic Adaptation ofMicroorganisms · 2020Review
- Application of Recombinase-Based In Vivo Expression Technology toMicroorganisms · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The non-digestible oligosaccharide fraction of maternal milk represents an important of carbohydrate and energy source for saccharolytic bifidobacteria in the gastrointestinal tract during early life. However, not all neonatal bifidobacteria isolates can directly metabolise the complex sialylated, fucosylated, sulphated and/or N-acetylglucosamine-containing oligosaccharide structures present in mothers milk. For some bifidobacterial strains, efficient carbohydrate syntrophy or crossfeeding is key to their establishment in the gut. In this study, we have adopted advanced functional genomic approaches to create single and double in-frame deletions of the N-acetyl glucosamine 6-phosphate deacetylase encoding genes, nagA1 and nagA2, of B. breve UCC2003. In vitro phenotypic analysis followed by in vivo studies on co-colonisation, mother to infant transmission, and evaluation of the relative co-establishment of B. bifidum and B. breve UCC2003 or UCC2003ΔnagA1ΔnagA2 in dam-reared neonatal mice demonstrates the importance of crossfeeding on sialic acid, fucose and N-acetylglucosamine-containing oligosaccharides for the establishment of B. breve UCC2003 in the neonatal gut. Furthermore, transcriptomic analysis of in vivo gene expression shows upregulation of genes associated with the utilisation of lactose, sialic acid, GlcNAc-6-S and fucose in B. breve UCC2003, while for UCC2003ΔnagA1ΔnagA2 only genes for lactose metabolism were upregulated.
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