Evidence map›Paper›PMID 30006481›Full record

ArticleClinical science (London, England : 1979)2018

Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease.

Mathew S Eapen, Anudeep Kota, Howard Vindin, Kielan D McAlinden, Dia Xenaki, Brian G Oliver, Deepak A Deshpande, Sukhwinder Singh Sohal, Pawan Sharma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical science (London, England : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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  11. ASK1 inhibition: a therapeutic strategy with multi-system benefits.Journal of molecular medicine (Berlin, Germany) · 2020
    Review
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Mathew S EapenRespiratory Translational Research Group, Department of Laboratory Medicine, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia.
Anudeep KotaWoolcock Emphysema Centre, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW 2037, Australia.
Howard VindinWoolcock Emphysema Centre, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW 2037, Australia.
Kielan D McAlindenWoolcock Emphysema Centre, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW 2037, Australia.
Dia XenakiWoolcock Emphysema Centre, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW 2037, Australia.
Brian G OliverWoolcock Emphysema Centre, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW 2037, Australia.
Deepak A DeshpandeDepartment of Medicine, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA 19107, U.S.A.
Sukhwinder Singh SohalRespiratory Translational Research Group, Department of Laboratory Medicine, College of Health and Medicine, University of Tasmania, Launceston, Tasmania 7248, Australia.
Pawan SharmaWoolcock Emphysema Centre, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW 2037, Australia Pawan.Sharma@uts.edu.au.
Woolcock Institute of Medical Research · AUUniversity of Tasmania · AUUniversity of Technology Sydney · AUUniversity of Sydney · AU

Funding

Functional Diversity of Compartmentalized Calcium Signaling in Airway Smooth MuscleR01HL137030 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI DESHPANDE, DEEPAK A · 2018 to 2021
$2.2M
Evaluation of novel substrate specific inhibitors of ERK1/2 in the treatment of asthmaR21AI126492 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DESHPANDE, DEEPAK A, SHAPIRO, PAUL S · 2016 to 2017
$440k
NHLBI NIH HHS R01 HL137030NIAID NIH HHS R21 AI126492
6 · The paper itself

Abstract

Increased airway smooth muscle (ASM) mass is observed in chronic obstructive pulmonary disease (COPD), which is correlated with disease severity and negatively affects lung function in these patients. Thus, there is clear unmet clinical need for finding new therapies which can target airway remodeling and disease progression in COPD. Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) activated by various stress stimuli, including reactive oxygen species (ROS), tumor necrosis factor (TNF)-α, and lipopolysaccharide (LPS) and is known to regulate cell proliferation. ASM cells from COPD patients are hyperproliferative to mitogens

Indexed as

Cell MovementCell ProliferationCells, CulturedEnzyme InhibitorsHumansLungMAP Kinase Kinase Kinase 5MAP Kinase Signaling SystemMitogensMuscle, SmoothMyocytes, Smooth MusclePulmonary Disease, Chronic ObstructiveRNA InterferenceTransforming Growth Factor beta1Enzyme InhibitorsMAP3K5 protein, humanMAP Kinase Kinase Kinase 5MitogensTransforming Growth Factor beta1airway remodellingairway smooth musclechronic obstructive pulmonary disease

Identifiers

PMID30006481
PMCPMC6218165
OpenAlexW2883813291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.