ArticleProceedings of the National Academy of Sciences of the United States of America2018
Time-resolved neural reinstatement and pattern separation during memory decisions in human hippocampus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Hippocampal patterns and associative memory: Distinct intracranial EEG temporal encoding patterns support memory.bioRxiv : the preprint server for biology · 2026Article
- Neural Representations of Reward-Related Memories Shift across Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Emotional learning selectively distorts the temporal organization of memory: A quantitative synthesis.Cognition · 2026Article
- From Sensory Details to Verbal Codes: Visual Memory Reinstatement of Location and Color Features.bioRxiv : the preprint server for biology · 2026Article
- MST in the wild: Optimizing the mnemonic similarity task for use in diverse environments.Neuropsychologia · 2026Article
- Temporal associations supporting repetitions in free recall.Psychonomic bulletin & review · 2025Article
- Embodiment in episodic memory through premotor-hippocampal coupling.Communications biology · 2024Article
- General knowledge and detailed memory benefit from different training sequences.Journal of applied research in memory and cognition · 2024Article
- The hippocampus dissociates present from past and future goals.Nature communications · 2024Article
- Awake ripples enhance emotional memory encoding in the human brain.Nature communications · 2024Article
- Segregation-to-integration transformation model of memory evolution.Network neuroscience (Cambridge, Mass.) · 2024Article
- Hippocampal integration and separation processes with different temporal and spatial dynamics during learning for associative memory.Human brain mapping · 2023Article
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- How our understanding of memory replay evolves.Journal of neurophysiology · 2023Review
- Stress disrupts insight-driven mnemonic reconfiguration in the medial temporal lobe.NeuroImage · 2023Article
- Optimizing the mnemonic similarity task for efficient, widespread use.Frontiers in behavioral neuroscience · 2023Article
- Mnemonic construction and representation of temporal structure in the hippocampal formation.Nature communications · 2022Article
- Predictive Representations in Hippocampal and Prefrontal Hierarchies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Mechanisms for Cognitive Impairment in Epilepsy: Moving Beyond Seizures.Frontiers in neurology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Mnemonic decision-making has long been hypothesized to rely on hippocampal dynamics that bias memory processing toward the formation of new memories or the retrieval of old ones. Successful memory encoding may be best optimized by pattern separation, whereby two highly similar experiences can be represented by underlying neural populations in an orthogonal manner. By contrast, successful memory retrieval is thought to be supported by a recovery of the same neural pattern laid down during encoding. Here we examined how hippocampal pattern completion and separation emerge over time during memory decisions. We measured electrocorticography activity in the human hippocampus and posterior occipitotemporal cortex (OTC) while participants performed continuous recognition of items that were new, repeated (old), or highly similar to a prior item (similar). During retrieval decisions of old items, both regions exhibited significant reinstatement of multivariate high-frequency activity (HFA) associated with encoding. Further, the extent of reinstatement of encoding patterns during retrieval was correlated with the strength (HFA power) of hippocampal encoding. Evidence for encoding pattern reinstatement was also seen in OTC on trials requiring fine-grained discrimination of similar items. By contrast, hippocampal activity showed evidence for pattern separation during these trials. Together, these results underscore the critical role of the hippocampus in supporting both reinstatement of overlapping information and separation of similar events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.