Evidence map›Paper›PMID 30006428›Full record

GuidelineJournal of the National Comprehensive Cancer Network : JNCCN2018

Anal Carcinoma, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

Al B Benson, Alan P Venook, Mahmoud M Al-Hawary, Lynette Cederquist, Yi-Jen Chen, Kristen K Ciombor, Stacey Cohen, Harry S Cooper, Dustin Deming, Paul F Engstrom and 24 more

Abstract readPractice Guideline
In one paragraph

Guideline in Journal of the National Comprehensive Cancer Network : JNCCN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Outcome following local excision of T1 anal cancers-a systematic review.International journal of colorectal disease · 2020
    Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Thirty-Two Years of Radiotherapy for T1 Anal Cancer: Patterns, Outcomes, and Side-effects at a Single Institution.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  9. Article
  10. An overview of clinical trials in anal cancer 1999-2024.ESMO gastrointestinal oncology · 2026
    Article
  11. Article
  12. Anal neoplasm in colonoscopy: What endoscopists need to know.World journal of gastrointestinal endoscopy · 2025
    Article
  13. Predictive value ofReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Article
  14. Anal and Perianal Masses: The Common, the Uncommon, and the Rare.The Indian journal of radiology & imaging · 2024
    Review
  15. Review
  16. Article
  17. PET/MRI in colorectal and anal cancers: an update.Abdominal radiology (New York) · 2023
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Al B Benson
Alan P Venook
Mahmoud M Al-Hawary
Lynette Cederquist
Yi-Jen Chen
Kristen K Ciombor
Stacey Cohen
Harry S Cooper
Dustin Deming
Paul F Engstrom
Jean L Grem
Axel Grothey
Howard S Hochster
Sarah Hoffe
Steven Hunt
Ahmed Kamel
Natalie Kirilcuk
Smitha Krishnamurthi
Wells A Messersmith
Jeffrey Meyerhardt
Mary F Mulcahy
James D Murphy
Steven Nurkin
Leonard Saltz
Sunil Sharma
David Shibata
John M Skibber
Constantinos T Sofocleous
Elena M Stoffel
Eden Stotsky-Himelfarb
Christopher G Willett
Evan Wuthrick
Kristina M Gregory
Deborah A Freedman-Cass

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
NCI NIH HHS K12 CA090625
6 · The paper itself

Abstract

The NCCN Guidelines for Anal Carcinoma provide recommendations for the management of patients with squamous cell carcinoma of the anal canal or perianal region. Primary treatment of anal cancer usually includes chemoradiation, although certain lesions can be treated with margin-negative local excision alone. Disease surveillance is recommended for all patients with anal carcinoma because additional curative-intent treatment is possible. A multidisciplinary approach including physicians from gastroenterology, medical oncology, surgical oncology, radiation oncology, and radiology is essential for optimal patient care.

Indexed as

Anal CanalAntineoplastic Combined Chemotherapy ProtocolsAnus NeoplasmsBiopsyCarcinoma, Squamous CellChemoradiotherapyColostomyDisease-Free SurvivalHumansMedical OncologyNeoplasm Recurrence, LocalPatient Care TeamRandomized Controlled Trials as TopicSocieties, MedicalUnited States

Identifiers

PMID30006428
PMCPMC10181270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.