Trial reportNeurology2018
The efficacy of nonpharmacologic intervention for orthostatic hypotension associated with aging.
Trial report in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Diagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson's disease: guideline "Parkinson's disease" of the German Society of Neurology.Journal of neurology · 2025Guideline
- Hemodynamic Effects of the Osmopressor Response: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2023Pooled it
- Acute effects of bolus water intake on post-exercise orthostatic hypotension and cardiovascular hemodynamics.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Trial
- Compression Stockings Improve Cardiac Output and Cerebral Blood Flow during Tilt Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Patients: A Randomized Crossover Trial.Medicina (Kaunas, Lithuania) · 2021Trial
- Combination non-pharmacologic intervention for orthostatic hypotension in older people: a phase 2 study.Age and ageing · 2020Trial
- Tolerability and efficacy of full-body head-up tilt sleeping in Parkinson's disease and multiple system atrophy.NPJ Parkinson's disease · 2026Article
- Coefficient of variation of R-R intervals during deep breathing as a risk marker of orthostatic blood pressure decline in patients with Type 2 diabetes mellitus.Nagoya journal of medical science · 2026Article
- How to treat cardiovascular autonomic failure in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Review
- Impact of scheduled water intake on mild cognitive impairment in patients with orthostatic hypotension.Scientific reports · 2025Article
- Physiological Targets for Orthostatic Hypotension: Improving Nonpharmacological Interventions in Patients with Orthostatic Cerebral Hypoperfusion.Applied psychophysiology and biofeedback · 2024Article
- Orthostatic Hypotension in Adults With Hypertension: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Non-Pharmacological Treatment of Autonomic Dysfunction in Parkinson's Disease and Other Synucleinopathies.Journal of Parkinson's disease · 2024Review
- Ampreloxetine Versus Droxidopa in Neurogenic Orthostatic Hypotension: A Comparative Review.Cureus · 2023Review
- Parkinson disease primer, part 2: management of motor and nonmotor symptoms.Canadian family physician Medecin de famille canadien · 2023Article
- Clinical management of amyloid cardiomyopathy.Heart failure reviews · 2022Review
- New horizons in the ageing autonomic nervous system: orthostatic hypotension and supine hypertension.Age and ageing · 2022Article
- Diagnosis and treatment of orthostatic hypotension.The Lancet. Neurology · 2022Review
- Strategies to improve uptake and adherence of non-pharmacologic interventions for orthostatic hypotension in older people: a qualitative study.European geriatric medicine · 2022Article
- Orthostatic Hypotension: Management of a Complex, But Common, Medical Problem.Circulation. Arrhythmia and electrophysiology · 2022Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the efficacy and safety of nonpharmacologic interventions for orthostatic hypotension (OH) secondary to aging.
methodsA total of 150 orthostatic challenges were performed in 25 older people (age 60-92 years) to determine cardiovascular responses to bolus water drinking, compression stockings, abdominal compression, and physical countermaneuvers. Primary outcome was response rate as assessed by proportion of participants whose systolic blood pressure (SBP) drop improved by ≥10 mm Hg.
resultsThe response rate to bolus water drinking was 56% (95% confidence interval [CI] 36.7-74.2), with standing SBP increasing by 12 mm Hg (95% CI 4-20). Physical countermaneuvers were efficacious in 44% (95% CI 25.8-63.3) but had little effect on standing SBP (+7.5 mm Hg [95% CI -1 to 16]). Abdominal compression was efficacious in 52% (95% CI 32.9-70.7) and improved standing SBP (+10 mm Hg [95% CI 2-18]). Compression stockings were the least efficacious therapy (32% [95% CI 16.1-51.4]) and had little effect on standing SBP (+6 mm Hg [95% CI -1, 13]). No intervention improved symptoms during standing. There were no adverse events.
conclusionsBolus water drinking should become the standard first-line nonpharmacologic intervention, whereas compression stockings should be disregarded in this population. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that for older people with OH, bolus water drinking is superior to other nonpharmacologic interventions in decreasing SBP drop.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.