ArticleNeurology2018
The spike onset zone: The region where epileptic spikes start and from where they propagate.
Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Negative BOLD response to interictal discharges in epilepsy using intracranial EEG-fMRI.Neuroimage. Reports · 2026Article
- Complementary predictive value of electromagnetic source imaging and hemodynamic responses in epilepsy surgery: A quantitative spatial analysis.Epilepsia · 2026Article
- Mesial-to-lateral gradients of epileptiform activity to localize mesial temporal lobe epilepsy.Epilepsia · 2025Article
- WISDEM: a hybrid wireless integrated sensing detector for simultaneous EEG and MRI.Nature methods · 2025Article
- Depth-to-scalp spatiotemporal dynamics for stereo-EEG.Epilepsy & behavior reports · 2025Article
- Spatio-temporal independent component classification for localization of seizure onset zone.Frontiers in neurology · 2025Article
- Co-activation of interictal epileptiform discharges localizes seizure onset zone and fluctuates with brain state.Brain communications · 2025Article
- Mapping interictal discharges using intracranial EEG-fMRI to predict postsurgical outcomes.Brain : a journal of neurology · 2024Article
- Estimation of fMRI responses related to epileptic discharges using Bayesian hierarchical modeling.Human brain mapping · 2023Article
- Passive and active markers of cortical excitability in epilepsy.Epilepsia · 2023Review
- Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy.Brain : a journal of neurology · 2023Article
- Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy.Scientific reports · 2023Article
- High-rate leading spikes in propagating spike sequences predict seizure outcome in surgical patients with temporal lobe epilepsy.Brain communications · 2023Article
- Multispectral intraoperative imaging for the detection of the hemodynamic response to interictal epileptiform discharges.Biomedical optics express · 2022Article
- Simultaneous EEG-fMRI: What Have We Learned and What Does the Future Hold?Sensors (Basel, Switzerland) · 2022Review
- fMRI-Based Effective Connectivity in Surgical Remediable Epilepsies: A Pilot Study.Brain topography · 2021Article
- How cerebral cortex protects itself from interictal spikes: The alpha/beta inhibition mechanism.Human brain mapping · 2021Article
- Making the Invisible Visible: Advanced Neuroimaging Techniques in Focal Epilepsy.Frontiers in neuroscience · 2021Review
- What Triggers the Interictal Epileptic Spike? A Multimodal Multiscale Analysis of the Dynamic of Synaptic and Non-synaptic Neuronal and Vascular Compartments Using Electrical and Optical Measurements.Frontiers in neurology · 2021Article
- Treatment of Epilepsy Associated with Periventricular Nodular Heterotopia.Current neurology and neuroscience reports · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether the maximum hemodynamic response to scalp interictal epileptic discharges (IEDs) corresponds to the region where IEDs originate and from where they propagate.
methodsWe studied 19 patients who underwent first an EEG-fMRI showing responses in the gray matter, and then intracranial EEG (iEEG). We coregistered the hemodynamic responses to the iEEG electrode contacts and analyzed IEDs in the iEEG channel adjacent to a maximum response (labeled the
resultsThe median latency of IEDs in the main channel was significantly smaller than in other channels for either the peak (15.5 vs 67.5 milliseconds,
conclusionIED adjacent to a maximum hemodynamic response, which often corresponds to the seizure onset zone, is more likely to precede IEDs in remote locations during a widespread intracranial discharge. Thus, EEG-fMRI is a unique noninvasive method to reveal the origin of IEDs, which we propose to label the spike onset zone.
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