Evidence map›Paper›PMID 30006396›Full record

ArticleApplied and environmental microbiology2018

Thiaminase I Provides a Growth Advantage by Salvaging Precursors from Environmental Thiamine and Its Analogs in Burkholderia thailandensis.

David R Sannino, Clifford E Kraft, Katie A Edwards, Esther R Angert

Open access · bronzeAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

David R SanninoDepartment of Microbiology, Cornell University, Ithaca, New York, USA.
Clifford E KraftDepartment of Natural Resources, Cornell University, Ithaca, New York, USA.
Katie A EdwardsDepartment of Microbiology, Cornell University, Ithaca, New York, USA.
Esther R AngertDepartment of Microbiology, Cornell University, Ithaca, New York, USA era23@cornell.edu.ORCID 0000-0002-4787-5264
Cornell University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiamine is essential to life, as it serves as a cofactor for enzymes involved in critical carbon transformations. Many bacteria can synthesize thiamine, while thiamine auxotrophs must obtain it or its precursors from the environment. Thiaminases degrade thiamine by catalyzing the base-exchange substitution of thiazole with a nucleophile, and thiaminase I specifically has been implicated in thiamine deficiency syndromes in animals. The biological role of this secreted enzyme has been a long-standing mystery. We used the thiaminase I-producing soil bacterium

Indexed as

Alkyl and Aryl TransferasesBacterial ProteinsBurkholderiaPyrimidinesThiamineThiazolesAlkyl and Aryl TransferasesBacterial ProteinspyrimidinePyrimidinesThiaminethiamin pyridinylaseThiazolesBurkholderia thailandensisHMPthiaminase IthiaminethiazolethiCthiG

Identifiers

PMID30006396
PMCPMC6122001
OpenAlexW2832902372

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.