Evidence map›Paper›PMID 30006375›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

IL-7 Enables Antibody Responses to Bacterial Polysaccharides by Promoting B Cell Receptor Diversity.

Gregory S Dickinson, Eric A Levenson, Justin A Walker, John F Kearney, Kishore R Alugupalli

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gregory S DickinsonDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107; and.
Eric A LevensonDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107; and.
Justin A WalkerDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107; and.
John F KearneyDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294.ORCID 0000-0003-2569-2560
Kishore R AlugupalliDepartment of Microbiology and Immunology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107; and kishore.alugupalli@jefferson.edu.

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI DANIEL P SILVER · 1995 to 2026
$94.8M
Regulation of B cell Clonal Diversity and Its Role in DiseaseR01AI014782 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEARNEY, JOHN FRANKLIN · 1985 to 2020
$7.1M
Effects of neonatal microbial exposure on anti-polysaccharide B cell developmentU01AI100005 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEARNEY, JOHN FRANKLIN · 2017 to 2021
$1.9M
Effects of neonatal microbial exposure on anti-polysaccharide B cell developmentR01AI100005 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEARNEY, JOHN FRANKLIN · 2012 to 2016
$1.8M
Regulation of bacterial polysaccharide-specific B cell responsesR56AI121270 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI ALUGUPALLI, KISHORE R · 2016 to 2016
$405k
REGULATION OF B CELL CLONAL DIVERSITYR21AI014782 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEARNEY, JOHN FRANKLIN · 2000 to 2000
$179k
Induction of polysaccharide vaccine responses in the young by interleukin-7R03AI105724 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI ALUGUPALLI, KISHORE R · 2014 to 2015
$155k
NCI NIH HHS P30 CA056036NIAID NIH HHS R01 AI014782NIAID NIH HHS R01 AI100005NIAID NIH HHS R03 AI105724NIAID NIH HHS R21 AI014782NIAID NIH HHS R56 AI121270NIAID NIH HHS U01 AI100005
6 · The paper itself

Abstract

Polysaccharide vaccines such as the Vi polysaccharide (ViPS) of

Indexed as

AnimalsAntibodies, BacterialAntibody DiversityAntibody FormationB-LymphocytesGenes, Immunoglobulin Heavy ChainImmunoglobulin Variable RegionInterleukin-7MiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutPolysaccharides, BacterialReceptors, Antigen, B-CellAntibodies, BacterialImmunoglobulin Variable RegionInterleukin-7interleukin-7, mousePolysaccharides, BacterialReceptors, Antigen, B-Cell

Identifiers

PMID30006375
PMCPMC6085875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.