Evidence map›Paper›PMID 30006296›Full record

ArticleBrain research2018

Chronic mild hypoxia increases expression of laminins 111 and 411 and the laminin receptor α6β1 integrin at the blood-brain barrier.

Sebok K Halder, Ravi Kant, Richard Milner

Abstract read
In one paragraph

Article in Brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Glycocalyx and basal lamina in neurological disorders.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Review
  3. Review
  4. Article
  5. Laminins and the blood-brain barrier.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  6. Article
  7. The importance of laminin at the blood-brain barrier.Neural regeneration research · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Human iPSC-Derived Blood Vessel Organoids for Studying Chronic Hypoxia-Induced Microvascular Dysfunction.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sebok K HalderDepartment of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address: skhalder@scripps.edu.
Ravi KantDepartment of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address: ravin@scripps.edu.
Richard MilnerDepartment of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address: rmilner@scripps.edu.
Scripps Research Institute · US

Funding

A vasculo-protective role for beta4 integrin in neuroinflammationR01NS103966 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI MILNER, D. RICHARD · 2018 to 2022
$2.1M
Vascular protection via alpha5beta1 integrin inhibition during neuroinflammationR21NS096524 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI BIX, GREGORY JAYE, MILNER, D. RICHARD · 2016 to 2017
$532k
The protective potential of mild hypoxia on inflammatory demyelinating diseaseR56NS095753 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI MILNER, D. RICHARD · 2016 to 2016
$385k
NINDS NIH HHS R01 NS103966NINDS NIH HHS R21 NS096524NINDS NIH HHS R56 NS095753
6 · The paper itself

Abstract

The laminin family of glycoproteins are major constituents of the basal lamina of blood vessels, and play a fundamental role in promoting endothelial differentiation and blood-brain barrier (BBB) stability. Chronic mild hypoxia (CMH), in which mice are exposed to 8% O

Indexed as

AnimalsBlood-Brain BarrierCerebrovascular DisordersEndothelial CellsFemaleHypoxiaIntegrin alpha6beta1LamininMiceVascular RemodelingIntegrin alpha6beta1LamininBlood-brain barrier (BBB)Central nervous systemHypoxiaIntegrinLamininVascular remodeling

Identifiers

PMID30006296
PMCPMC6231956
OpenAlexW2858222287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.