Evidence map›Paper›PMID 30006274›Full record

ArticleExperimental eye research2018

Establishment of a conditionally immortalized mouse optic nerve astrocyte line.

Yang Liu, Gaurang C Patel, Weiming Mao, Abbot F Clark

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Immortalization Reversibility in the Context of Cell Therapy Biosafety.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yang LiuNorth Texas Eye Research Institute, Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United States. Electronic address: yang.liu@unthsc.edu.
Gaurang C PatelNorth Texas Eye Research Institute, Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United States.
Weiming MaoNorth Texas Eye Research Institute, Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United States.
Abbot F ClarkNorth Texas Eye Research Institute, Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United States.
University of North Texas · USUniversity of North Texas Health Science Center · US

Funding

Novel Genome Editing for the Treatment of GlaucomaR01EY030366 · NEI · UNIVERSITY OF IOWA · PI CLARK, ABBOT FREDERICK, SHEFFIELD, VAL C. · 2019 to 2023
$2.7M
Conditionally immortalized TM cell and RGC lines from Animal ModelR21EY023364 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI CLARK, ABBOT FREDERICK · 2014 to 2015
$323k
NEI NIH HHS R01 EY030366NEI NIH HHS R21 EY023364
6 · The paper itself

Abstract

Optic nerve astrocytes play a major role in axonal degeneration and regeneration. Astrocyte lines are an important tool to elucidate the responsible cellular mechanisms. In this study, we established a conditionally immortalized mouse optic nerve astrocyte line. Astrocytes were cultured from explants derived from postnatal day 4-5 H-2k

Indexed as

AnimalsAntigens, Polyomavirus TransformingAstrocytesBlotting, WesternCD56 AntigenCell Culture TechniquesCell LineCell ProliferationFlow CytometryGlial Fibrillary Acidic ProteinImmunohistochemistryKaryotypingMiceMice, TransgenicOptic NervePhagocytosisAntigens, Polyomavirus TransformingCD56 AntigenGlial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseNcam1 protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53Cell lineConditional immortalizationOptic nerve astrocyte

Identifiers

PMID30006274
PMCPMC6215719
OpenAlexW2865872598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.