ArticleExperimental eye research2019
Fixation instability during binocular viewing in anisometropic and strabismic children.
Article in Experimental eye research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07226141 (Valproate for the Treatment of Residual Amblyopia), which is not on this map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Valproate for the Treatment of Residual Amblyopia
Who cites it
54 citing papers in PubMed, 77 citations in OpenAlex.
- Abnormal Fixational Eye Movements in Ophthalmic Disease: Implications for Visual Function and Clinical Assessment.Journal of eye movement research · 2026Review
- Machine Learning-Based Prediction of Strabismus with and without Amblyopia from Fixation Eye Movements.Ophthalmology science · 2026Article
- Analysis of Convergence and Divergence Using an Eye Tracker in Acquired Comitant Esotropia.Investigative ophthalmology & visual science · 2026Article
- Severity-dependent Disruption of Binocular Accommodative Amplitude And Near Fusional Reserves in Children with Hyperopic Anisometropia.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Altered Spontaneous Brain Activity in Adolescents and Adults with Comitant Strabismus and Strabismic Amblyopia.Ophthalmology science · 2026Article
- Application of Eye-Tracking Technology in Assessing Binocular Vision Function in Paediatric Populations: A Scoping Review.Journal of eye movement research · 2026Review
- The Changing Natural History of Anisometropia: A Scoping Review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Pilot comparison of monocular and binocular modes of virtual reality field testing in strabismus.Scientific reports · 2025Article
- Slow binocular reading during rapid serial visual presentation (RSVP) in children with amblyopia and the role of fixation instability.Vision research · 2025Article
- Eye-hand coordination during visually-guided reaching in children with monocular deprivation amblyopia.Vision research · 2025Article
- Vergence anomalies are associated with impaired stereopsis in amblyopia.Vision research · 2025Article
- Determining fixation accuracy with optical coherence tomography and its implication on visual acuity in amblyopia.Vision research · 2025Article
- Eye tracking for the classification of visual function in individuals with vision impairment: A validation in Para athletes.Journal of vision · 2025Article
- Article
- The impact of eye movements on amblyopic vision: A mini-review.Vision research · 2025Review
- Fixation Stability of the Right and Left Eyes Under Binocular and Monocular Viewing Conditions.Life (Basel, Switzerland) · 2025Article
- Differential Impacts of Strabismic and Anisometropic Amblyopia on the Mesoscale Functional Organization of the Human Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Poor fixation stability does not account for motion perception deficits in amblyopia.Scientific reports · 2025Article
- Transformative Gamified Binocular Therapy for Unilateral Amblyopia in Young Children: Pilot Prospective Efficacy and Safety Study.JMIR serious games · 2025Article
- Fixation Stability Deficits in Anisometropic Amblyopia.Investigative ophthalmology & visual science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeStrabismus or anisometropia disrupts binocularity and results in fixation instability, which is increased with amblyopia. Fixation instability has typically been assessed for each eye individually. Recently, vergence instability was reported in exotropic adults and monkeys during binocular viewing. We evaluated fixation instability during binocular viewing in children treated for anisometropia and/or strabismus.
methods160 children age 4-12 years with treated esotropia and/or anisometropia (98 amblyopic, 62 nonamblyopic) were compared to 46 age-similar controls. Fixation instability was recorded during binocular fixation of a 0.3 deg diameter dot for 20 s using a 500 Hz remote video binocular eye tracker (EyeLink 1000; SR Research). The bivariate contour ellipse area (BCEA; log deg
resultsWhen binocularly viewing, both amblyopic and nonamblyopic children treated for anisometropia and/or strabismus had larger fixation instability and vergence instability than controls. Amblyopia primarily added to the instability of the nonpreferred eye. Anisometropic children had less nonpreferred eye instability and vergence instability than those with strabismus or combined mechanism. Nonpreferred eye instability and vergence instability were related to poorer stereoacuity and a larger suppression scotoma. Preferred eye instability was not related to any visual outcome measure. No relationships were found with visual acuity.
conclusionsFixation instability and vergence instability during binocular viewing suggests that discordant binocular visual experience during childhood, especially strabismus, interferes with ocular motor development. Amblyopia adds to instability of the nonpreferred eye. Vergence instability may limit potential for recovery of binocular vision in these children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.