ReviewTrends in molecular medicine2018
The Impact of Systemic Inflammation on Neurodevelopment.
Review in Trends in molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05298748 (Womb Recordings and Respiratory Control Maturation in Neonates), which is not on this map. Cited by 180 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Womb Recordings and Respiratory Control Maturation in Neonates
Who cites it
180 citing papers in PubMed, 8 syntheses or guidelines pooled it, 325 citations in OpenAlex.
- Neuropsychiatric disorders in children of mothers with polycystic ovary syndrome: a systematic review and meta-analysis.BMC psychiatry · 2026Pooled it
- Pooled it
- Peripheral Blood Monocytes as Biomarkers of Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis.Research on child and adolescent psychopathology · 2025Pooled it
- The Link Between Positive and Negative Parenting Behaviors and Child Inflammation: A Systematic Review.Child psychiatry and human development · 2023Pooled it
- Molecular Mechanisms of ZIKV-Induced Teratogenesis: A Systematic Review of Studies in Animal Models.Molecular neurobiology · 2023Pooled it
- Effects of probiotics on neurocognitive outcomes in infants and young children: a meta-analysis.Frontiers in public health · 2023Pooled it
- Is there any association between dietary inflammatory index and quality of life? A systematic review.Frontiers in nutrition · 2022Pooled it
- Association of Peripheral Blood Levels of Cytokines With Autism Spectrum Disorder: A Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- Associations of Serum Inflammatory Biomarkers During Pregnancy With Placental Pathology and Placental Gene Expression at Delivery.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Trial
- Assessing environmental exposures in children: toward a comprehensive exposome approach.Pediatric research · 2026Review
- PEGylated Liposomal Resveratrol Induces Region-Specific Redox Modulation Without Behavioral or Neurotrophin Recovery in a VPA Model of Autism.Journal of molecular neuroscience : MN · 2026Article
- Peripheral Hematological and Immune-Endocrine Markers in Children with Specific Learning Disorder: An Exploratory Retrospective Case-Control Study.Brain sciences · 2026Article
- Special Issue "Alcohol and Inflammation".International journal of molecular sciences · 2026Article
- Practitioner Review: Infant mental health meets cell and molecular biology - a look to the future.Journal of child psychology and psychiatry, and allied disciplines · 2026Review
- Neurological and neurodevelopmental effects of Covid and MIS-C on children.Pediatric research · 2026Review
- Maternal sleep deprivation and developmental programming of brain aging trajectories in offspring.Biogerontology · 2026Review
- Placental and juvenile immune responses to maternal immune activation are differentially regulated by sex chromosomes and gonads across gestation.Journal of neuroinflammation · 2026Article
- Early Gut Microbiota and Neurodevelopmental Trajectories: Implications for Pediatric Neuropsychiatric Vulnerability-A Narrative Review.Nutrients · 2026Review
- Narrative Review "Dual Frontiers in Neurodegeneration: Pharmacological Synergies and Divergences in Parkinson's Disease and Type 2 Diabetes Mellitus".Cellular and molecular neurobiology · 2026Review
- From Breath to Brain: NICU respiratory interventions and bedside brain signal entropy predict later autism risk.Developmental cognitive neuroscience · 2026Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Inflammatory mediators affect the brain during development. Neurodevelopmental disorders such as autism spectrum disorders, cognitive impairment, cerebral palsy, epilepsy, and schizophrenia have been linked to early life inflammation. Recent advances have shown the effects of systemic inflammation on children's neurodevelopment. We discuss the potential mechanisms by which inflammatory molecules can exert their effects on the developing brain and consider the roles of MHC class I molecules, the HPA axis, glial cells, and monoamine metabolism. Methods to prevent the effects of cytokine imbalance may lead to the development of new therapeutics for neuropsychiatric disorders. Future research should focus on identifying at-risk individuals and early effective interventions to prevent long-term neurodevelopmental disabilities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.