Evidence map›Paper›PMID 30005828›Full record

Observational studyJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society2018

Age-related heterogeneity in dental caries and associated risk factors in individuals with cystic fibrosis ages 6-20 years: A pilot study.

Donald L Chi, Margaret Rosenfeld, Lloyd Mancl, Whasun O Chung, Richard B Presland, Elise Sarvas, Marilynn Rothen, Alaa Alkhateeb, Sharon McNamara, Alan Genatossio and 3 more

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Association of dental diseases with pulmonary outcomes in a multicenter cohort of adolescents and young adults with CF.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Observational
  3. Article
  4. Oral health and related outcomes in children and adolescents with cystic fibrosis: a scoping review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Donald L ChiUniversity of Washington, School of Dentistry, Department of Oral Health Sciences, Box 357475, Seattle, WA 98195, USA. Electronic address: dchi@uw.edu.
Margaret RosenfeldSeattle Children's Hospital, Cystic Fibrosis Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA.
Lloyd ManclUniversity of Washington, School of Dentistry, Department of Oral Health Sciences, Box 357475, Seattle, WA 98195, USA.
Whasun O ChungUniversity of Washington, School of Dentistry, Department of Oral Health Sciences, Box 357475, Seattle, WA 98195, USA.
Richard B PreslandUniversity of Washington, School of Dentistry, Department of Oral Health Sciences, Box 357475, Seattle, WA 98195, USA; University of Washington, Department of Medicine, Division of Dermatology, Box 356524, Seattle, WA 98195, USA.
Elise SarvasUniversity of Minnesota, School of Dentistry, Department of Pediatric Dentistry, 515 Delaware Street SE, Minneapolis, MN 55455, USA.
Marilynn RothenUniversity of Washington, School of Dentistry, Department of Oral Health Sciences, Box 357475, Seattle, WA 98195, USA.
Alaa AlkhateebUniversity of Washington, School of Dentistry, Department of Oral Health Sciences, Box 357475, Seattle, WA 98195, USA.
Sharon McNamaraSeattle Children's Hospital, Cystic Fibrosis Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA.
Alan GenatossioSeattle Children's Hospital, Cystic Fibrosis Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA.
Isabel Virella-LowellUniversity of Alabama - Birmingham, Division of Pediatric Pulmonology and Sleep Medicine, 1600 7th Ave S, Birmingham, AL 35233, USA.
Carlos MillaStanford University Medical School, 770 Welch Rd, Ste. 350, Palo Alto, CA 94304, USA.
JoAnna ScottUniversity of Missouri - Kansas City, School of Dentistry, Department of Dental Public, Health and Behavioral Science, 650 E. 25th St., Kansas City, MO 64108, USA.
University of Washington · USSeattle Children's Hospital · USStanford University · USUniversity of Alabama at Birmingham · USUniversity of Minnesota · USUniversity of Missouri–Kansas City · US

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss · 2010 to 2026
$21.4M
Comprehensive Training in Inter-Disciplinary Oral Health ResearchT90DE021984 · NIDCR · UNIVERSITY OF WASHINGTON · PI Robert Aaron Cornell · 2012 to 2026
$7.9M
Addressing Oral Health Disparities in Medicaid-Enrolled Special Needs Children wiK08DE020856 · NIDCR · UNIVERSITY OF WASHINGTON · PI CHI, DONALD LESLIE · 2010 to 2014
$627k
NCATS NIH HHS UL1 TR002319NIDCR NIH HHS K08 DE020856NIDCR NIH HHS T90 DE021984NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

backgroundThe literature conflicts regarding dental caries risk in cystic fibrosis (CF) relative to controls.

methodsProspective, observational study of age-related heterogeneity in caries rates and potential risk factors in individuals with CF ages 6-20 at a single clinic in Washington state (N=85). Caries rates for enrolled CF participants and historical controls from NHANES were compared using cubic spline regression models. Generalized linear regression models identified correlates of age and caries in CF.

resultsChildren ages 6-9 with CF had significantly lower caries than controls (Holm's P<0.05). There was no difference for ages 10-20 by CF status (Holm's P>0.05). Various biological/intraoral, medical, and behavioral factors were associated with caries and age in CF.

conclusionsYounger children with CF may be protected from caries, but there is apparent loss of protection in early adolescence associated with multiple risk factors. Additional studies are needed to confirm these findings.

Indexed as

Dental CariesAdolescentAdolescent HealthChildCystic FibrosisFemaleHumansMaleOral HealthPilot ProjectsProspective StudiesRisk AssessmentRisk FactorsUnited StatesYoung AdultCaries risk factorsCystic fibrosisDental cariesPediatric dentistry

Identifiers

PMID30005828
PMCPMC6589399
OpenAlexW2860619874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.