ArticleBMC geriatrics2018
Clinical Frailty Scale (CFS) reliably stratifies octogenarians in German ICUs: a multicentre prospective cohort study.
Article in BMC geriatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03134807 (The Very Old Intensive Care Patient), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Very Old Intensive Care Patient: A Multinational Prospective Observation Study
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methods of Assessing Frailty in the Critically Ill: A Systematic Review of the Current Literature.Gerontology · 2022Pooled it
- Prevention at home in older persons with (pre-)frailty: analysis of participants' recruitment and characteristics of the randomized controlled PromeTheus trial.Aging clinical and experimental research · 2024Trial
- [The geriatric syndrome frailty in the context of readmission to the intensive care unit : Study protocol of a mixed-methods study].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Article
- Frailty at ICU admission: a potential alternative to scoring systems based on clinical observation.Internal and emergency medicine · 2026Article
- Limited prognostic value of the neutrophil-to-lymphocyte ratio compared with severity scores for mortality prediction in elderly critically ill patients.Critical care science · 2026Article
- Non-home discharge in the octogenarian and nonagenarian colorectal cancer population: a retrospective cohort study.International journal of colorectal disease · 2025Observational
- Predictors of outcomes of patients ≥ 80 years old admitted to intensive care units in Poland - a post-hoc analysis of the VIP2 prospective observational study.Anaesthesiology intensive therapy · 2024Observational
- Differences in directives to limit treatment and discontinue mechanical ventilation between elderly and very elderly patients: a substudy of a multinational observational study.Intensive care medicine · 2023Observational
- Impact of frailty on long-term mortality in older patients receiving intensive care via the emergency department.Scientific reports · 2023Observational
- Factors influencing conveyance of older adults with minor head injury by paramedics to the emergency department: a multiple methods study.BMC emergency medicine · 2022Article
- Performance of the APOP-screener for predicting in-hospital mortality in older COVID-19 patients: a retrospective study.BMC geriatrics · 2022Article
- Sex Difference in Control of Low-Density Lipoprotein Cholesterol in Older Patients after Acute Coronary Syndrome.Geriatrics (Basel, Switzerland) · 2022Article
- [Palliative care for patients over 80 years old with COVID‑19 pneumonia on the intensive care unit-Is invasive ventilation effective?]Wiener medizinische Wochenschrift (1946) · 2022Article
- The Clinical Frailty Scale as useful tool in patients with brain metastases.Journal of neuro-oncology · 2022Article
- Which Frailty Evaluation Method Can Better Improve the Predictive Ability of the SASA for Postoperative Complications of Patients Undergoing Elective Abdominal Surgery?Therapeutics and clinical risk management · 2022Article
- Frailty Triage: Is Rationing Intensive Medical Treatment on the Grounds of Frailty Ethical?The American journal of bioethics : AJOB · 2021Review
- Management and outcomes in critically ill nonagenarian versus octogenarian patients.BMC geriatrics · 2021Article
- Frailty is associated with poor prognosis after resection for pancreatic cancer.International journal of clinical oncology · 2021Article
- Validation of the revised 9-scale clinical frailty scale (CFS) in Greek language.BMC geriatrics · 2021Article
- Article
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn intensive care units (ICU) octogenarians become a routine patients group with aggravated therapeutic and diagnostic decision-making. Due to increased mortality and a reduced quality of life in this high-risk population, medical decision-making a fortiori requires an optimum of risk stratification. Recently, the VIP-1 trial prospectively observed that the clinical frailty scale (CFS) performed well in ICU patients in overall-survival and short-term outcome prediction. However, it is known that healthcare systems differ in the 21 countries contributing to the VIP-1 trial. Hence, our main focus was to investigate whether the CFS is usable for risk stratification in octogenarians admitted to diversified and high tech German ICUs.
methodsThis multicentre prospective cohort study analyses very old patients admitted to 20 German ICUs as a sub-analysis of the VIP-1 trial. Three hundred and eight patients of 80 years of age or older admitted consecutively to participating ICUs. CFS, cause of admission, APACHE II, SAPS II and SOFA scores, use of ICU resources and ICU- and 30-day mortality were recorded. Multivariate logistic regression analysis was used to identify factors associated with 30-day mortality.
resultsPatients had a median age of 84 [IQR 82-87] years and a mean CFS of 4.75 (± 1.6 standard-deviation) points. More than half of the patients (53.6%) were classified as frail (CFS ≥ 5). ICU-mortality was 17.3% and 30-day mortality was 31.2%. The cause of admission (planned vs. unplanned), (OR 5.74) and the CFS (OR 1.44 per point increase) were independent predictors of 30-day survival.
conclusionsThe CFS is an easy determinable valuable tool for prediction of 30-day ICU survival in octogenarians, thus, it may facilitate decision-making for intensive care givers in Germany.
trial registrationThe VIP-1 study was retrospectively registered on ClinicalTrials.gov (ID: NCT03134807 ) on May 1, 2017.
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