ArticleBMC psychiatry2018
Correlations between exploratory eye movement, hallucination, and cortical gray matter volume in people with schizophrenia.
Article in BMC psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- A Comparative Multimodal Meta-analysis of Anisotropy and Volume Abnormalities in White Matter in People Suffering From Bipolar Disorder or Schizophrenia.Schizophrenia bulletin · 2022Pooled it
- Exploratory eye movement characteristics to aid screening of schizophrenia and bipolar disorder: A cross-sectional outpatient study.Scientific reports · 2026Article
- Eye Movement Patterns as Robust Biomarkers for Schizophrenia Identification Using a Novel Data Transformation Approach.Journal of eye movement research · 2026Article
- Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Predictive neural processing of self-generated hand and tool actions in patients with schizophrenia spectrum disorders and healthy individuals.Translational psychiatry · 2025Article
- Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry.International journal of ophthalmology · 2025Article
- Correlation Between Cortical Thickness Abnormalities of the Olfactory Sulcus and Olfactory Identification Disorder and Persistent Auditory Verbal Hallucinations in Chinese Patients With Chronic Schizophrenia.Schizophrenia bulletin · 2024Article
- Exploring the impact of biological alterations in the superior thalamic radiations on exploratory eye movements in attenuated psychosis syndrome.Frontiers in psychiatry · 2024Article
- Differential associations of adolescent versus young adult cannabis initiation with longitudinal brain change and behavior.Molecular psychiatry · 2023Article
- Electroencephalographic Effective Connectivity Analysis of the Neural Networks during Gesture and Speech Production Planning in Young Adults.Brain sciences · 2023Article
- Abnormal functional connectivity of the salience network in insomnia.Brain imaging and behavior · 2022Article
- Altered brain activity in the bilateral frontal cortices and neural correlation with cognitive impairment in schizophrenia.Brain imaging and behavior · 2022Article
- Abnormal Brain Network Interaction Associated With Positive Symptoms in Drug-Naive Patients With First-Episode Schizophrenia.Frontiers in psychiatry · 2022Article
- Eye movement characteristics in male patients with deficit and non-deficit schizophrenia and their relationships with psychiatric symptoms and cognitive function.BMC neuroscience · 2021Article
- Comparison of resting-state spontaneous brain activity between treatment-naive schizophrenia and obsessive-compulsive disorder.BMC psychiatry · 2021Article
- Recent updates of eye movement abnormalities in patients with schizophrenia: A scoping review.Psychiatry and clinical neurosciences · 2021Article
- Common and Distinct Alterations of Cognitive Function and Brain Structure in Schizophrenia and Major Depressive Disorder: A Pilot Study.Frontiers in psychiatry · 2021Article
- Towards Clinically Relevant Oculomotor Biomarkers in Early Schizophrenia.Frontiers in behavioral neuroscience · 2021Article
- Eye movement characteristics in schizophrenia: A recent update with clinical implications.Neuropsychopharmacology reports · 2020Review
- Hybrid Functional Brain Network With First-Order and Second-Order Information for Computer-Aided Diagnosis of Schizophrenia.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWidespread cortical gray matter alternations in people with schizophrenia are correlated with both psychotic symptoms and cognitive/behavioral abnormalities, including the impairments of exploratory eye movement (EEM). Particularly, the loss of gray matter density is specifically related to deficits of the responsive search score (RSS) of EEM in schizophrenia. It is unknown, however, whether the schizophrenia-related RSS deficits are associated with certain psychotic symptoms, such as hallucinations.
methodsIn 33 participants with schizophrenia, the measurement of EEM, assessment of the hallucination severity using Positive and Negative Syndrome Scale (PANSS) and a voxel-based morphometric analysis of cortical gray matter volume (GMV) were conducted to investigate the relationships between the RSS of EEM, symptom severity, and GMV. In 29 matched healthy controls, the measurement of EEM and a voxel-based morphometric analysis of cortical GMV were also conducted to investigate the relationship between the RSS of EEM and GMV.
resultsIn participants with schizophrenia, the hallucination severity was significantly negatively correlated with both the RSS and the GMV of a large number of brain regions in the frontal, temporal, parietal, orbitofrontal, calcarine, cingulate, and insular cortices, and rolandic operculum, hippocampus, parahippocampal gyrus, and thalamus. Also in participants with schizophrenia, the RSS was significantly positively correlated with the GMV in the left supplementary motor area (SMA), left superior frontal cortex (SFG), bilateral precentral gyri, bilateral postcentral gyri, and bilateral middle frontal cortices. More importantly, the GMV of the SMA, SFG, and precentral gyrus in the left hemisphere was not only significantly negatively correlated with the hallucination severity but also significantly positively correlated with the RSS. No significant correlation could be revealed between the RSS and the GMV of any brain regions in healthy controls.
conclusionsThere was a significantly negative association between the hallucination severity and the RSS of EEM, suggesting that the RSS may be a potential biomarker for predicting the hallucination severity of schizophrenia. Also, the GMV of the left SMA, SFG, and precentral gyrus may be the common substrates underlying both hallucination induction and the RSS in people with schizophrenia.
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