Evidence map›Paper›PMID 30005288›Full record

ArticleColloids and surfaces. B, Biointerfaces2018

Tailoring weight ratio of PCL/PLA in electrospun three-dimensional nanofibrous scaffolds and the effect on osteogenic differentiation of stem cells.

Tao Xu, Qingqing Yao, Jacob M Miszuk, Hanna J Sanyour, Zhongkui Hong, Hongli Sun, Hao Fong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Colloids and surfaces. B, Biointerfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tao XuProgram of Biomedical Engineering, South Dakota School of Mines and Technology, Rapid City, SD 57701, USA.
Qingqing YaoDepartment of Biomedical Engineering, University of South Dakota, BioSNTR, Sioux Falls, SD 57107, USA.
Jacob M MiszukDepartment of Biomedical Engineering, University of South Dakota, BioSNTR, Sioux Falls, SD 57107, USA.
Hanna J SanyourDepartment of Biomedical Engineering, University of South Dakota, BioSNTR, Sioux Falls, SD 57107, USA.
Zhongkui HongDepartment of Biomedical Engineering, University of South Dakota, BioSNTR, Sioux Falls, SD 57107, USA.
Hongli SunDepartment of Biomedical Engineering, University of South Dakota, BioSNTR, Sioux Falls, SD 57107, USA. Electronic address: Hongli.Sun@usd.edu.
Hao FongProgram of Biomedical Engineering, South Dakota School of Mines and Technology, Rapid City, SD 57701, USA. Electronic address: Hao.Fong@sdsmt.edu.

Funding

Functionalized Nanofibrous Scaffold for Endogenous Bone RegenerationR03DE027491 · NIDCR · UNIVERSITY OF SOUTH DAKOTA · PI SUN, HONGLI · 2018 to 2019
$304k
NIDCR NIH HHS R03 DE027491
6 · The paper itself

Abstract

Three-dimensional (3D) scaffolds as artificial ECMs have been extensively studied to mimic the critical features of natural ECMs. To develop more clinically relevant 3D scaffolds, electrospun nanofibrous scaffolds with different weight ratios of PCL/PLA (i.e., 100/0, 60/40, and 20/80) were fabricated via the thermally induced (nanofiber) self-agglomeration (TISA) method. The hypothesis was that, with the weight ratio increase of stiffer and more bioactive PLA in the 3D PCL/PLA blend scaffolds, the osteogenic differentiation of human mesenchymal stem cells (hMSCs) would be enhanced. The results indicated that, all of the 3D scaffolds were elastic/resilient and possessed interconnected and hierarchical pores with sizes from sub-microns to ∼300 μm; therefore, the morphological structures of these scaffolds were similar to those of natural ECMs. The PLA80 scaffolds exhibited the best overall properties in terms of density, porosity, water absorption capacity, mechanical properties, bioactivity, and cell viability. Furthermore, with increasing the PLA weight ratio, the alkaline phosphatase (ALP) activity, calcium content, and gene expression level were also increased, probably due to the improved stiffness/bioactivity of scaffold. Hence, the novel 3D electrospun PLA80 nanofibrous scaffold might be desired/favorable for the osteogenic differentiation of hMSCs.

Indexed as

Cell DifferentiationCell SurvivalHumansMesenchymal Stem CellsNanofibersOsteogenesisParticle SizePolyestersSurface PropertiespolycaprolactonePolyesterspoly(lactide)3D scaffoldBone tissue engineeringDifferentiationElectrospinningNanofiberOsteogenic

Identifiers

PMID30005288
PMCPMC6174100

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.