ArticleJournal of hypertension2018
Procedural and anatomical predictors of renal denervation efficacy using two radiofrequency renal denervation catheters in a porcine model.
Article in Journal of hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- A preclinical study of combined hepatic and renal artery denervation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- Multi-Organ Denervation: The Past, Present and Future.Journal of clinical medicine · 2025Review
- Response of Blood Pressure to Renal Denervation Is Not Associated With Genetic Variants.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Catheter-based renal sympathetic nerve denervation on hypertension management outcomes.World journal of radiology · 2022Article
- Device-Based Sympathetic Nerve Regulation for Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2021Review
- Development and Evaluation of a Disease Large Animal Model for Preclinical Assessment of Renal Denervation Therapies.Animals : an open access journal from MDPI · 2020Article
- Procedural and Anatomical Determinants of Multielectrode Renal Denervation Efficacy.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Renal Denervation: Is It Ready for Prime Time?Current cardiology reports · 2019Review
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSeveral renal denervation (RDN) systems are currently under investigation for treatment of hypertension by ablation of renal sympathetic nerves. The procedural efficacy of devices, however, is variable and incompletely understood. This study aimed at investigating procedural and anatomical predictors of RDN efficacy by comparing two radiofrequency catheter systems in a porcine model.
methodsDomestic swine were assigned into two treatment groups (n = 10) and one sham group (n = 3). Bilateral RDN in main and in branch segments of renal arteries was performed using two different multielectrode catheter systems [Symplicity Spyral (SPY) and IberisBloom (IBB)]. After 7 days, measurement of norepinephrine (NEPI) tissue concentrations and histological analyses have been performed.
resultsRenal NEPI tissue concentration following RDN was significantly reduced when compared with Sham (SPY: -95 ± 3% vs. Sham, P < 0.001; IBB: -88 ± 11% vs. Sham, P < 0.001). Histological evaluation showed comparable lesion depth and lesion area (lesion depth: SPY-main 6.26 ± 1.62 mm vs. SPY-branch 3.49 ± 1.11 mm; IBB-main 5.93 ± 1.88 mm vs. IBB-branch: 3.26 ± 1.26 mm, P < 0.001; lesion area: SPY-main 43.5 ± 29.5 mm vs. SYP-branch 45.0 ± 38.0 mm; IBB-main 52.3 ± 34.8 mm vs. IBB-branch 44.0 ± 42.6 mm, P = 0.77; intergroup SPY vs. IBB, P = 0.73). Histological investigations documented a significant correlation between number of ablations per millimeter length of renal artery and reduction in NEPI tissue concentration.
conclusionThe two devices under investigation demonstrated similar histopathological lesion characteristics and similar reduction of renal NEPI levels. An increase in number of ablations per millmeter length of renal artery resulted in improved efficacy and reduced variability in treatment effects.
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