Evidence map›Paper›PMID 30004811›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Noninvasive wave intensity analysis predicts functional worsening in children with pulmonary arterial hypertension.

Michal Schäfer, Neil Wilson, D Dunbar Ivy, Richard Ing, Steven Abman, Lorna P Browne, Gareth Morgan, Michael Ross, Daniel McLennan, Alex J Barker and 4 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Wave intensity analysis with exercise identifies impairments in pulmonary hypertension.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Comparison of arterial wave intensity analysis by pressure-velocity and diameter-velocity methods in a virtual population of adult subjects.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2020
    Article
  15. Cardiovascular magnetic resonance imaging derived septal curvature in neonates with bronchopulmonary dysplasia associated pulmonary hypertension.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Article
  16. Article
  17. Observational
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Michal SchäferDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Neil WilsonDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
D Dunbar IvyDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Richard IngDivision of Pediatric Cardiac Anesthesiology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Steven AbmanDivision of Pulmonology, Breathing Institute, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Lorna P BrowneDepartment of Radiology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Gareth MorganDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Michael RossDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Daniel McLennanDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Alex J BarkerDepartment of Radiology, Feinberg School of Medicine, Northwestern University , Chicago, Illinois.
Brian FonsecaDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Michael Di MariaDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Kendall S HunterDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Uyen TruongDivision of Cardiology, Heart Institute, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · USChildren's Hospital Colorado · USNorthwestern University · US

Funding

Hemodynamic Loading of the Left Ventricle and Aorta in Aortic Valve DiseaseK25HL119608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARKER, ALEXANDER J. · 2014 to 2018
$819k
6 · The paper itself

Abstract

The purpose of the present study was to characterize pulmonary vascular stiffness using wave intensity analysis (WIA) in children with pulmonary arterial hypertension (PAH), compare the WIA indexes with catheterization- and MRI-derived hemodynamics, and assess the prognostic ability of WIA-derived biomarkers to predict the functional worsening. WIA was performed in children with PAH ( n = 40) and healthy control subjects ( n = 15) from phase-contrast MRI-derived flow and area waveforms in the main pulmonary artery (MPA). From comprehensive WIA spectra, we collected and compared with healthy control subjects forward compression waves (FCW), backward compression waves (BCW), forward decompression waves (FDW), and wave propagation speed ( c-MPA). There was no difference in the magnitude of FCW between PAH and control groups (88 vs. 108 mm

Indexed as

Arterial PressureMagnetic Resonance ImagingPulse Wave AnalysisVascular StiffnessAdolescentAge FactorsCardiac CatheterizationChildDisease ProgressionFemaleHumansHypertension, PulmonaryMalePredictive Value of TestsPrognosisProspective Studiesmagnetic resonance imagingpediatric pulmonary arterial hypertensionvascular stiffness

Identifiers

PMID30004811
PMCPMC6737454
OpenAlexW2883966738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.