Evidence map›Paper›PMID 30004398›Full record

ReviewVaccines2018

Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System.

Mona O Mohsen, Ariane C Gomes, Monique Vogel, Martin F Bachmann

Abstract readReview
In one paragraph

Review in Vaccines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed.

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  19. Nonlytic Egress and Transmission in the Virus World.Annual review of biochemistry · 2025
    Review
  20. Review

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mona O MohsenJenner Institute, University of Oxford, Oxford OX3 7BN, UK. mmohsen@qf.org.qa.ORCID 0000-0003-3510-9148
Ariane C GomesJenner Institute, University of Oxford, Oxford OX3 7BN, UK. ariane.cruzgomes@kellogg.ox.ac.uk.
Monique VogelInselspital, Universitatsklinik RIA, Immunologie, 3010 Bern, Switzerland. monique.vogel@dbmr.unibe.ch.
Martin F BachmannJenner Institute, University of Oxford, Oxford OX3 7BN, UK. martin.bachmann@ndm.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. This review discusses the interaction of viral capsid-derived VLPs with the innate immune system.

Indexed as

adaptive immune systeminnate immune systemToll-like receptor (TLR)virus-like particle (VLP)

Identifiers

PMID30004398
PMCPMC6161069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.