Evidence map›Paper›PMID 30004239›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Proteomics reveals Rictor as a noncanonical TGF-β signaling target during aneurysm progression in Marfan mice.

Sarah J Parker, Aleksandr Stotland, Elena MacFarlane, Nicole Wilson, Amanda Orosco, Vidya Venkatraman, Kyle Madrid, Roberta Gottlieb, Harry C Dietz, Jennifer E Van Eyk

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Skeletal muscle alterations in Marfan syndrome: a systematic review.Journal of muscle research and cell motility · 2025
    Pooled it
  2. Review
  3. Fibronectin-induced overactivation of αNature communications · 2026
    Article
  4. Growth arrest of thoracic aortic aneurysms in aging Marfan mice.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  5. Integrin Signaling Pathways in Aortic Aneurysm and Dissection.Reviews in cardiovascular medicine · 2026
    Review
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  20. Therapies for Thoracic Aortic Aneurysms and Acute Aortic Dissections.Arteriosclerosis, thrombosis, and vascular biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sarah J ParkerAdvanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, California.
Aleksandr StotlandMolecular Cardiobiology, The Heart Institute, Cedars-Sinai Medical Center , Los Angeles, California.
Elena MacFarlaneInstitute for Genetic Medicine, Johns Hopkins University , Baltimore, Maryland.
Nicole WilsonInstitute for Genetic Medicine, Johns Hopkins University , Baltimore, Maryland.
Amanda OroscoAdvanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, California.
Vidya VenkatramanAdvanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, California.
Kyle MadridBiomedical Sciences, Cedars-Sinai Medical Center , Los Angeles, California.
Roberta GottliebMolecular Cardiobiology, The Heart Institute, Cedars-Sinai Medical Center , Los Angeles, California.ORCID 0000-0002-1432-006X
Harry C DietzInstitute for Genetic Medicine, Johns Hopkins University , Baltimore, Maryland.
Jennifer E Van EykAdvanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, California.
Cedars-Sinai Medical Center · USJohns Hopkins University · USHoward Hughes Medical Institute · US

Funding

Surgery, Physiology and ImmunohistopathologyP01HL085577 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI BROWN, JOAN HELLER · 2006 to 2017
$18.4M
Genomic and Proteomic Architecture of AtherosclerosisR01HL111362 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HERRINGTON, DAVID MCLEOD · 2012 to 2021
$17.2M
Protein Chemistry and ProteomicsP01HL112730 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI VAN EYK, JENNIFER E · 2013 to 2017
$12.0M
Mitochondrial Turnover in the Human HeartR01HL132075 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI GOTTLIEB, ROBERTA A., VAN EYK, JENNIFER E · 2017 to 2020
$2.1M
The vessel wall as a paracrine engine in TGF beta-induced aortic aneurysmR00HL121287 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GALLO MACFARLANE, ELENA · 2017 to 2019
$727k
The vessel wall as a paracrine engine in TGF beta-induced aortic aneurysmK99HL121287 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GALLO MACFARLANE, ELENA · 2014 to 2015
$228k
NHLBI NIH HHS K99 HL121287NHLBI NIH HHS P01 HL085577NHLBI NIH HHS P01 HL112730NHLBI NIH HHS R00 HL121287NHLBI NIH HHS R01 HL111362NHLBI NIH HHS R01 HL132075
6 · The paper itself

Abstract

The objective of the present study was to 1) analyze the ascending aortic proteome within a mouse model of Marfan syndrome (MFS; Fbn1

Indexed as

AnimalsAortaAortic AneurysmCell MovementCell ProliferationCells, CulturedChromatography, High Pressure LiquidDilatation, PathologicDisease Models, AnimalDisease ProgressionFibrillin-1Genetic Predisposition to DiseaseIntegrin beta3MaleMarfan SyndromeMass SpectrometryFibrillin-1Integrin beta3Protein Serine-Threonine KinasesRapamycin-Insensitive Companion of mTOR Proteinrictor protein, mouseScaffold Protein ILKTransforming Growth Factor betaaortic aneurysmdata-independent acquisition mass spectrometryintegrin signalingMarfan syndromeRictortransforming growth factor-β

Identifiers

PMID30004239
PMCPMC6335018
OpenAlexW2884472648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.