ArticleHaemophilia : the official journal of the World Federation of Hemophilia2018
Risk factors for cardiovascular disease in children and young adults with haemophilia.
Article in Haemophilia : the official journal of the World Federation of Hemophilia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Thrombin generation to evaluate the complex hemostatic balance of hemophilia A plasma containing direct oral anticoagulant and supplemented by factor VIII.Research and practice in thrombosis and haemostasis · 2024Article
- Cardiovascular Risk Factors in Patients with Congenital Hemophilia: A Focus on Hypertension.Diagnostics (Basel, Switzerland) · 2022Review
- Current Choices and Management of Treatment in Persons with Severe Hemophilia A without Inhibitors: A Mini-Delphi Consensus.Journal of clinical medicine · 2022Article
- The Role of Physiotherapy in the New Treatment Landscape for Haemophilia.Journal of clinical medicine · 2021Review
- Feasibility, safety and acceptability of select outcome measures in a physiotherapy study protocol for boys with haemophilia.Pilot and feasibility studies · 2021Article
- Evaluation of Unfavorable Cardiovascular and Metabolic Risk Factors in Children and Young Adults with HaemophiliaJournal of clinical research in pediatric endocrinology · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
introductionThe origins of cardiovascular disease (CVD) begin in childhood. The primary objective of this cross-sectional cohort study was to determine the prevalence of cardiovascular risk factors in patients with congenital haemophilia A or B followed at Rady Children's Hospital San Diego Hemophilia and Thrombosis Treatment Center (HTC). We hypothesized that cardiovascular risk factors could be identified as part of a comprehensive clinic visit. MATERIALS AND
methodsStandardized measurement of weight, height, waist circumference and blood pressure plus non-fasting glucose and lipid panel were performed. Participants and/or caregivers completed questionnaires about family history, medical history and lifestyle. Clinical data were abstracted from the medical record. Descriptive statistics, Student's t test, correlation, Mann-Whitney U test and chi-square test were performed to analyse the data.
resultsForty-three males (mean 12 years, range 5-20 years) enrolled. High rates of overweight and obesity, (pre)hypertension and abnormal lipids were identified. Subjects with normal weight had more days of >60 minutes of physical activity compared with those with overweight or obesity (5.2 ± 2.4 vs. 3.8 ± 2.5 day; P = 0.07). Higher weight was correlated with higher factor consumption (cor = 0.88; P < 0.001). There was no difference in target joints based on weight category (30% in normal weight vs. 25% in overweight or obese, χ
conclusionsModifiable risk factors for CVD were identified as part of the study during comprehensive clinic visits. The HTC team may develop behavioural interventions to target cardiovascular risk reduction as part of the comprehensive care model.
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