Evidence map›Paper›PMID 30003945›Full record

ArticleNeurochemistry international2018

Fast and slow-twitching muscles are differentially affected by reduced cholinergic transmission in mice deficient for VAChT: A mouse model for congenital myasthenia.

Matheus P S Magalhães-Gomes, Daisy Motta-Santos, Luana P L Schetino, Jéssica N Andrade, Cristiane P Bastos, Diogo A S Guimarães, Sydney K Vaughan, Patrícia M Martinelli, Silvia Guatimosim, Grace S Pereira and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemistry international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Matheus P S Magalhães-GomesDepartamento de Morfologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Daisy Motta-SantosDepartamento de Fisiologia e Biofísica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Departamento de Esportes, EEFFTO, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Luana P L SchetinoDepartamento de Morfologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Jéssica N AndradeDepartamento de Morfologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Cristiane P BastosDepartamento de Fisiologia e Biofísica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Diogo A S GuimarãesIEP-Santa Casa, Belo Horizonte, MG, Brazil.
Sydney K VaughanVirginia Tech Carilion Research Institute, Roanoke, VA, USA; Graduate Program in Translational Biology, Medicine, and Health, Virginia Tech, Blacksburg, VA, USA.
Patrícia M MartinelliDepartamento de Morfologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Silvia GuatimosimDepartamento de Fisiologia e Biofísica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Grace S PereiraDepartamento de Fisiologia e Biofísica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Candido C CoimbraDepartamento de Fisiologia e Biofísica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Vânia F PradoRobarts Research Institute and Department of Physiology and Pharmacology and Anatomy & Cell Biology, University of Western Ontario, London, ON, Canada.
Marco A M PradoRobarts Research Institute and Department of Physiology and Pharmacology and Anatomy & Cell Biology, University of Western Ontario, London, ON, Canada.
Gregorio ValdezVirginia Tech Carilion Research Institute, Roanoke, VA, USA; Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA.
Cristina GuatimosimDepartamento de Morfologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: cguati@icb.ufmg.br.
Universidade Federal de Minas Gerais · BRCarilion Clinic · USWestern University · CAGrupo Santa Casa de Belo Horizonte · BR

Funding

Targeting the fibroblast growth factor binding protein-1 to slow degeneration of neuromuscular junctionsR01AG055545 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2017 to 2021
$2.2M
Role of Target-derived FGFs in Maintaining and Repairing SynapsesK01NS085071 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2013 to 2015
$679k
Synaptic FGFs are required and sufficient to maintain and repair aged NMJsR56AG051501 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2015 to 2015
$377k
NIA NIH HHS R01 AG055545NIA NIH HHS R56 AG051501NINDS NIH HHS K01 NS085071
6 · The paper itself

Abstract

Congenital myasthenic syndromes (CMS) result from reduced cholinergic transmission at neuromuscular junctions (NMJs). While the etiology of CMS varies, the disease is characterized by muscle weakness. To date, it remains unknown if CMS causes long-term and irreversible changes to skeletal muscles. In this study, we examined skeletal muscles in a mouse line with reduced expression of Vesicular Acetylcholine Transporter (VAChT, mouse line herein called VAChT-KD

Indexed as

AcetylcholineAnimalsDisease Models, AnimalMice, TransgenicMuscle, SkeletalMyasthenic Syndromes, CongenitalNeuromuscular JunctionSynaptic VesiclesVesicular Acetylcholine Transport ProteinsAcetylcholineVesicular Acetylcholine Transport ProteinsAcetylcholineCholinergic transmissionCongenital myasthenic syndromesMotor functionVesicular acetylcholine transporter skeletal muscle

Identifiers

PMID30003945
PMCPMC6421860
OpenAlexW2875073569

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.