Evidence map›Paper›PMID 30003630›Full record

SynthesisAddiction (Abingdon, England)2018

Genome-wide association meta-analysis of age at first cannabis use.

Camelia C Minică, Karin J H Verweij, Peter J van der Most, Hamdi Mbarek, Manon Bernard, Kristel R van Eijk, Penelope A Lind, Meng Zhen Liu, Dominique F Maciejewski, Teemu Palviainen and 60 more

Open access · bronzeAbstract readMeta-AnalysisTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Addiction (Abingdon, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

70 authors at 20 institutions in 7 countries.

Camelia C MinicăDepartment of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, the Netherlands.ORCID 0000-0001-7140-8167
Karin J H VerweijDepartment of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, the Netherlands.ORCID 0000-0001-9868-7821
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0001-8450-3518
Hamdi MbarekDepartment of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, the Netherlands.
Manon BernardHospital for Sick Children Research Institute, Toronto, Canada.
Kristel R van EijkDepartment of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Penelope A LindPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Meng Zhen LiuInstitute for Behavioral Genetics, Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Dominique F MaciejewskiDepartment of Clinical Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Cristina Sánchez-MoraPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Richard ShervaBiomedical Genetics Department, Boston University School of Medicine, Boston, MA, USA.
Michelle TaylorMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.
Raymond K WaltersAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Abdel AbdellaouiDepartment of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, the Netherlands.
Timothy B BigdeliDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Susan J T BranjeResearch Centre Adolescent Development, Utrecht University, Utrecht, the Netherlands.
Sandra A BrownDepartment of Psychology and Psychiatry, University of California San Diego, La Jolla, CA, USA.
Miguel CasasPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Robin P CorleyInstitute for Behavioral Genetics, Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-2938-4170
George Davey-SmithMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.
Gareth E DaviesAvera Institute for Human Genetics, Sioux Falls, SD, USA.
Erik A EhliAvera Institute for Human Genetics, Sioux Falls, SD, USA.
Lindsay FarrerDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
Iryna O FedkoDepartment of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, the Netherlands.
Iris Garcia-MartínezPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Scott D GordonGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Catharina A HartmanDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Ian B HickieBrain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
Matthew HickmanSchool of Social and Community Medicine, University of Bristol, Bristol, UK.ORCID 0000-0001-9864-459X
Christian J HopferDepartment of Psychiatry, University of Colorado Denver, Aurora, CO, USA.
Jouke Jan HottengaDepartment of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, the Netherlands.
René S KahnDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455
Tellervo KorhonenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Henry R KranzlerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-1018-0450
Ken KrauterDepartment of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.
Pol A C van LierDepartment of Clinical Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Michael C NealeDepartment of Psychiatry and School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0003-4887-659X
Wim H J MeeusResearch Centre Adolescent Development, Utrecht University, Utrecht, the Netherlands.
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Albertine J OldehinkelDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Zdenka PausovaHospital for Sick Children Research Institute, Toronto, Canada.
Josep A Ramos-QuirogaPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Vanesa RichartePsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Richard J RoseDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Jean ShinHospital for Sick Children Research Institute, Toronto, Canada.
Michael C StallingsInstitute for Behavioral Genetics, Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Tamara L WallDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-0605-8660
Jennifer J WareMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.
Margaret J WrightQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Hongyu ZhaoDepartment of Biostatistics, Yale School of Public Health and VA CT, New Haven, CT, USA.
Hans M KootDepartment of Clinical Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Tomas PausRotman Research Institute, Baycrest, Toronto, Canada.
John K HewittInstitute for Behavioral Genetics, Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Marta RibasésPsychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Anu LoukolaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Marco P BoksDepartment of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Marcus R MunafòMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.ORCID 0000-0002-4049-993X
Joel GelernterPsychiatry, Genetics, and Neuroscience, Yale University School of Medicine and VA CT, West Haven, CT, USA.
Dorret I BoomsmaDepartment of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, the Netherlands.ORCID 0000-0002-7099-7972
Nicholas G MartinGenetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Nathan A GillespieDepartment of Psychiatry, Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0001-8655-2823
Jacqueline M VinkBehavioral Science Institute, Radboud University, Nijmegen, the Netherlands.
Eske M DerksDepartment of Psychiatry, Academic Medical Centre, Amsterdam, the Netherlands.ORCID 0000-0002-6292-6883
Tinbergen Institute · NLUniversitat Autònoma de Barcelona · ESQIMR Berghofer Medical Research Institute · AUUniversity Medical Center Groningen · NLUniversity of Bristol · GBUniversity of Colorado Boulder · USUniversity of Helsinki · FIUniversity Medical Center Utrecht · NLVirginia Commonwealth University · USAvera Health · USBoston University · USHospital for Sick Children · CARadboud University Nijmegen · NLThe University of Queensland · AUUniversity of Applied Sciences Utrecht · NLUniversity of California San Diego · USUniversity of Toronto · CAVrije Universiteit Amsterdam · NLWashington University in St. Louis · USYale University · US

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
Twin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5M
Sex-specific analysis of opioid dependence GWAS and beyondR01DA012690 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2000 to 2017
$14.0M
PILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1999 to 2008
$12.6M
GENETICS OF COCAINE DEPENDENCER01DA012849 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1999 to 2010
$11.5M
THE GENETICS OF VULNERABILITY TO NICOTINE ADDICTIONSR01DA012854 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2000 to 2013
$10.4M
The development of alcohol misuse and related problems from adolescence to early midlifeR01AA015416 · NIAAA · WASHINGTON UNIVERSITY · PI DICK, DANIELLE M, SALVATORE, JESSICA E · 2005 to 2024
$7.6M
GENETICS OF ADOLESCENT ANTISOCIAL DRUG DEPENDENCER01DA012845 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 2000 to 2012
$7.1M
Integration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5M
Linkage Disequilibrium Studies of Alcohol DependenceR01AA011330 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1997 to 2013
$6.4M
Genetics and Progression of Early-onset Substance Dependence and HIV RiskR01DA035804 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HOPFER, CHRISTIAN J, STALLINGS, MICHAEL CRAIG · 2014 to 2018
$4.9M
Molecular Epidemiology of Alcoholism 3 - EDAC FamiliesR01AA013321 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2001 to 2005
$4.3M
Brain & Behavior Research Foundation NARSAD Young Investigator GrantEuropean Research Council ERC-284167Foundation Volksbond RotterdamMedical Research Council G0800612Medical Research Council G0802736Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/7Medical Research Council MC_UU_12013/6Medical Research Council MR/K023233/1Medical Research Council MR/L022206/1NHGRI NIH HHS N01 HG065403NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA014041NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R01 AA017535NIAAA NIH HHS R37 AA007728NIAAA NIH HHS R37 AA012502NIAAA NIH HHS T32 AA007580NICHD NIH HHS R01 HD042157NIDA NIH HHS DA-018673NIDA NIH HHS K08 DA019951NIDA NIH HHS P60 DA011015NIDA NIH HHS R00 DA023549NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012845NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA018267NIDA NIH HHS R01 DA018432NIDA NIH HHS R01 DA018660NIDA NIH HHS R01 DA018673NIDA NIH HHS R01 DA021905NIDA NIH HHS R01 DA021913NIDA NIH HHS R01 DA023668NIDA NIH HHS R01 DA035804NIDA NIH HHS R37 DA018673NIDA NIH HHS R56 DA012854NIDA NIH HHS RC2 DA028909NIMH NIH HHS R01 MH081802NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U01 MH094432NIMH NIH HHS U24 MH068457NWO NWO 480-05-003US National Institutes of Health, National Institute on Drug Abuse R00DA023549Wellcome Trust
6 · The paper itself

Abstract

BACKGROUND AND

aimsCannabis is one of the most commonly used substances among adolescents and young adults. Earlier age at cannabis initiation is linked to adverse life outcomes, including multi-substance use and dependence. This study estimated the heritability of age at first cannabis use and identified associations with genetic variants.

methodsA twin-based heritability analysis using 8055 twins from three cohorts was performed. We then carried out a genome-wide association meta-analysis of age at first cannabis use in a discovery sample of 24 953 individuals from nine European, North American and Australian cohorts, and a replication sample of 3735 individuals.

resultsThe twin-based heritability for age at first cannabis use was 38% [95% confidence interval (CI) = 19-60%]. Shared and unique environmental factors explained 39% (95% CI = 20-56%) and 22% (95% CI = 16-29%). The genome-wide association meta-analysis identified five single nucleotide polymorphisms (SNPs) on chromosome 16 within the calcium-transporting ATPase gene (ATP2C2) at P < 5E-08. All five SNPs are in high linkage disequilibrium (LD) (r

conclusionAge at cannabis initiation appears to be moderately heritable in western countries, and individual differences in onset can be explained by separate but correlated genetic liabilities. The significant association between age of initiation and ATP2C2 is consistent with the role of calcium signalling mechanisms in substance use disorders.

Indexed as

Age of OnsetAdolescentAdultCalcium-Transporting ATPasesFemaleGenome-Wide Association StudyHumansMaleMarijuana UseMiddle AgedPolymorphism, Single NucleotideTwinsYoung AdultATP2C2 protein, humanCalcium-Transporting ATPasesAge at first useATP2C2cannabis initiationgenome-wide associationheritabilitysubstance use

Identifiers

PMID30003630
PMCPMC7087375
OpenAlexW2883697839

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.