Evidence map›Paper›PMID 30003558›Full record

ArticleBiomedical chromatography : BMC2018

Quantitative determination of armodafinil in human plasma by liquid chromatography-electrospray mass spectrometry: Application to a clinical study.

Hardik Chandasana, Johannes Kast, Janina A Bittman, Hartmut Derendorf

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical chromatography : BMC, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Intranasal hydrogel of armodafinil hydroxypropyl-β-cyclodextrin inclusion complex for the treatment of post-traumatic stress disorder.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hardik ChandasanaDepartment of Pharmaceutics, University of Florida, Gainesville, Gainesville, Florida, USA.ORCID http://orcid.org/0000-0002-1289-0800
Johannes KastDepartment of Pharmaceutics, University of Florida, Gainesville, Gainesville, Florida, USA.
Janina A BittmanDepartment of Pharmaceutics, University of Florida, Gainesville, Gainesville, Florida, USA.
Hartmut DerendorfDepartment of Pharmaceutics, University of Florida, Gainesville, Gainesville, Florida, USA.
University of Florida · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NIH/NCATS Clinical and Translational Science AwardPharmacy Recurring Opportunity Seed Program for Education and Research (PROSPER)
6 · The paper itself

Abstract

Armodafinil is a wake-promoting agent approved in 2007 by the US Food and Drug Administration for the treatment of excessive sleepiness. A rapid, sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of armodafinil in human plasma was developed and validated. Armodafinil and internal standard (armodafinil d-10) were extracted from human plasma using protein precipitation combined with liquid-liquid extraction. This developed method only requires 50 μL of plasma for the analysis. The chromatographic separation was performed with a Waters symmetry, C

Indexed as

Benzhydryl CompoundsChromatography, LiquidDrug StabilityHumansLinear ModelsModafinilReproducibility of ResultsSensitivity and SpecificitySpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryBenzhydryl CompoundsModafinilArclinical studyLC-MS/MSmodafinilpharmacokinetics

Identifiers

PMID30003558
PMCPMC6191358
OpenAlexW2883874129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.