ReviewThe journal of headache and pain2018
Medication-overuse headache: a widely recognized entity amidst ongoing debate.
Review in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07568496 (Greater Occipital Nerve Block for Migraine With Medication Overuse Headache), which is not on this map. Cited by 92 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Greater Occipital Nerve Block for Migraine With Medication Overuse Headache
Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it, 197 citations in OpenAlex.
- Peripheral nerve block in patients with medication-overuse headache: systematic review and meta-analysis.BMC neurology · 2026Pooled it
- Long-term real-world effectiveness and safety of fremanezumab in 1140 patients with migraine and at least 6 months of treatment: third interim analysis of the pan-European PEARL study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Trial
- Rimegepant orally disintegrating tablet 75 mg for acute treatment of migraine in adults from China: a subgroup analysis of a double-blind, randomized, placebo-controlled, phase 3 clinical trial.The journal of headache and pain · 2024Trial
- Quantity changes in acute headache medication use among patients with chronic migraine treated with eptinezumab: subanalysis of the PROMISE-2 study.The journal of headache and pain · 2022Trial
- Treatment benefit among migraine patients taking fremanezumab: results from a post hoc responder analysis of two placebo-controlled trials.The journal of headache and pain · 2021Trial
- The impact of fremanezumab on medication overuse in patients with chronic migraine: subgroup analysis of the HALO CM study.The journal of headache and pain · 2020Trial
- Glymphatic-Hippocampal Axis Alterations Across the Migraine-Medication Exposure Continuum: A Multi-modal Neuroimaging Study.Pain and therapy · 2026Article
- Two-Year Outcomes and Interictal Burden After Treatment for Medication Overuse Headache.Journal of clinical medicine · 2026Article
- Periventricular diffusivity at the ventricular-parenchymal interface across healthy controls, episodic migraine, and chronic migraine: a cross-sectional multimodal MRI study.The journal of headache and pain · 2026Article
- Pharmacist-led responses to headache and insomnia symptoms: A simulated patient study.Exploratory research in clinical and social pharmacy · 2026Article
- An exploration of possible future non-pharmacological multidisciplinary treatments to potentiate withdrawal strategy and recovery from medication overuse headache (MOH): a narrative review.Journal of oral & facial pain and headache · 2026Review
- Hallmarks of headache disorders: part 5 - secondary headaches.The journal of headache and pain · 2026Review
- The relationship between triglyceride levels and medication overuse headache in patients with chronic migraine.Journal of oral & facial pain and headache · 2026Article
- Prevalence, medication use, and health care utilization in pediatric primary headache: a school-based cross-sectional study.The journal of headache and pain · 2026Article
- Clinical profile and final diagnoses of hospitalized patients with a chief complaint of headache, an experience from a headache tertiary center in Iran.BMC neurology · 2026Article
- Article
- Real-World Clinical Effectiveness and Migraine-Related Healthcare Resource Utilization in Patients Initiating Fremanezumab in Germany and the United Kingdom.Therapeutics and clinical risk management · 2026Article
- Triple network disruption in medication overuse headache: functional signatures and clinical impact.The journal of headache and pain · 2025Article
- Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches.Brain and behavior · 2025Article
- Validation of a Self-Screening Questionnaire for Medication Overuse Headache (SSQ-MOH) in a Thai University-based Hospital Headache Clinic.The journal of headache and pain · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 10 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medication overuse in primary headache disorders is a worldwide phenomenon and has a role in the chronification of headache disorders. The burden of disease on individuals and societies is significant due to high costs and comorbidities. In the Third Edition of the International Classification of Headache Disorders, medication-overuse headache is recognized as a separate secondary entity next to mostly primary headache disorders, although many clinicians see the disease as a sole complication of primary headache disorders. In this review, we explore the historical background of medication-overuse headache, its epidemiology, phenomenology, pathophysiology and treatment options. The review explores relevant unanswered questions and summarizes the current debates in medication-overuse headache.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.