Evidence map›Paper›PMID 30003391›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2018

Differential expression of cyclooxygenase-2 and cyclin D1 in salivary gland tumors.

Jefferson da Rocha Tenório, Leorik Pereira da Silva, Marília Gabriela de Aguiar Xavier, Thalita Santana, George João Ferreira do Nascimento, Ana Paula Veras Sobral

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jefferson da Rocha TenórioDepartment of Oral Pathology and Special Care Patients, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227-Butantã, São Paulo, SP, Zip code: 05508-900, Brazil. jeffersonrtenorio@usp.br.ORCID http://orcid.org/0000-0002-6986-9148
Leorik Pereira da SilvaOral Pathology, Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte-UFRN, Natal, Rio Grande Do Norte, Brazil.
Marília Gabriela de Aguiar XavierOral Pathology, School of Dentistry, University of Pernambuco, Camaragibe, PE, Brazil.
Thalita SantanaDepartment of Oral Pathology and Special Care Patients, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227-Butantã, São Paulo, SP, Zip code: 05508-900, Brazil.
George João Ferreira do NascimentoBiological Sciences Academic Center, School of Dentistry, Federal University of Campina Grande-UFCG, Patos, Paraíba, Brazil.
Ana Paula Veras SobralOral Pathology, School of Dentistry, University of Pernambuco, Camaragibe, PE, Brazil.
Universidade de Pernambuco · BRUniversidade de São Paulo · BRUniversidade Federal de Campina Grande · BRUniversidade Federal do Rio Grande do Norte · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSalivary gland tumors are complex and have a great histomorphological diversity; more than 30 histological subtypes are currently described and the study of proteins that help understand and differentiate these tumors is essential. We aimed to analyze the immunoexpression of cyclooxygenase-2 (COX-2) and cyclin D1 proteins in pleomorphic adenomas (PA), mucoepidermoid carcinomas (MEC) and adenoid cystic carcinomas (AdCC) of salivary glands.

methodsA total of 38 PA, 12 AdCC and 12 MEC underwent immunohistochemical study by the polymeric biotin-free technique. Immunopositive cells were analyzed semi-quantitatively. For statistical analysis, a significance level was set at p ≤ 0.05.

resultsOverall, these tumors were more prevalent in women (n = 37). The mean age of these patients was 58-year-old and the parotid gland was the most affected anatomic site (n = 33). All cases of AdCC and MEC showed immunopositivity to cyclin D1; however, 39.5% of the PAs were negative (p < 0.001). Regarding COX-2 immunoexpression, we observed that all cases of CME were positive, whereas 60.5% of the PA and 75% of the CAC analyzed were completely negative (p = 0.042).

conclusionsThe overexpression of COX-2, observed only in MEC, emphasizes that salivary gland tumors have different profiles. Cyclin D1 is more immunoexpressed in malignant tumors. Together, these immunohistochemical findings may be useful in differentiating the studied tumors.

Indexed as

Adenoma, PleomorphicAdultBiomarkers, TumorCarcinoma, Adenoid CysticCarcinoma, MucoepidermoidCyclin D1Cyclooxygenase 2FemaleHumansMaleMiddle AgedSalivary Gland NeoplasmsBiomarkers, TumorCCND1 protein, humanCyclin D1Cyclooxygenase 2Cell cycleImmunohistochemistryInflammationSalivary gland tumors

Identifiers

PMID30003391
OpenAlexW2828697421

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.