ArticleWorld journal of urology2019
Unintended consequences of decreased PSA-based prostate cancer screening.
Article in World journal of urology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Changing times: trends in risk classification, tumor upstaging, and positive surgical margins after radical prostatectomy - results from a contemporary National Cancer Database study.World journal of urology · 2024Article
- [Risk-adapted early detection program for prostate cancer 2.0-position paper of the German Society of Urology 2024].Urologie (Heidelberg, Germany) · 2024Article
- Trends in prostate cancer incidence among Black men in the Caribbean and the United States.The Prostate · 2023Article
- Personalizing approaches to the management of metastatic hormone sensitive prostate cancer: role of advanced imaging, genetics and therapeutics.World journal of urology · 2023Article
- Increasing aggressive prostate cancer.The Canadian journal of urology · 2022Article
- Variations in Age-Adjusted Prostate Cancer Incidence Rates by Race and Ethnicity After Changes in Prostate-Specific Antigen Screening Recommendation.JAMA network open · 2022Article
- Changes in prostate cancer survival among insured patients in relation to USPSTF screening recommendations.BMC urology · 2022Article
- Novel Dormancy Mechanism of Castration Resistance in Bone Metastatic Prostate Cancer Organoids.International journal of molecular sciences · 2022Article
- Trends in Incidence of Metastatic Prostate Cancer in the US.JAMA network open · 2022Article
- Changing trends in robot-assisted radical prostatectomy: Inverse stage migration-A retrospective analysis.Prostate international · 2021Article
- Associations of Prostate-Specific Antigen (PSA) Testing in the US Population: Results from a National Cross-Sectional Survey.Journal of community health · 2021Article
- Impact of the evolving United States Preventative Services Task Force policy statements on incidence and distribution of prostate cancer over 15 years in a statewide cancer registry.Prostate international · 2021Article
- Impact on prostate cancer clinical presentation after non-screening policies at a tertiary-care medical center- a retrospective study.BMC urology · 2021Article
- Influence of Urethra Sparing on Tumor Control Probability and Normal Tissue Complication Probability in Focal Dose Escalated Hypofractionated Radiotherapy: A Planning Study Based on Histopathology Reference.Frontiers in oncology · 2021Article
- The changing landscape of cancer in the USA - opportunities for advancing prevention and treatment.Nature reviews. Clinical oncology · 2020Review
- National trends in the management of low-risk prostate cancer: analyzing the impact of Medicaid expansion in the United States.International urology and nephrology · 2020Article
- Impact of surgically maximized versus native membranous urethral length on 30-day and long-term pad-free continence after robot-assisted radical prostatectomy.Prostate international · 2020Article
- A Trend Toward Aggressive Prostate Cancer.Reviews in urology · 2020Article
- Trends in Prostate Cancer Prevalence and Radical Prostatectomy Rate according to Age Structural Changes in South Korea between 2005 and 2015.Yonsei medical journal · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn May 2012, the US Preventive Services Task Force issued a grade D recommendation against PSA-based prostate cancer screening. Epidemiologists have concerns that an unintended consequence is a problematic increase in high-risk disease and subsequent prostate cancer-specific mortality. MATERIALS AND
methodsTo assess the effect of decreased PSA screening on the presentation of high-risk prostate cancer post-radical prostatectomy (RP). Nine high-volume referral centers throughout the United States (n = 19,602) from October 2008 through September 2016 were assessed and absolute number of men presenting with GS ≥ 8, seminal vesicle and lymph node invasion were compared with propensity score matching.
resultsCompared to the 4-year average pre-(Oct. 2008-Sept. 2012) versus post-(Oct. 2012-Sept. 2016) recommendation, a 22.6% reduction in surgical volume and increases in median PSA (5.1-5.8 ng/mL) and mean age (60.8-62.0 years) were observed. The proportion of low-grade GS 3 + 3 cancers decreased significantly (30.2-17.1%) while high-grade GS 8 + cancers increased (8.4-13.5%). There was a 24% increase in absolute numbers of GS 8+ cancers. One-year biochemical recurrence rose from 6.2 to 17.5%. To discern whether increases in high-risk disease were due to referral patterns, propensity score matching was performed. Forest plots of odds ratios adjusted for age and PSA showed significant increases in pathologic stage, grade, and lymph node involvement.
conclusionsAll centers experienced consistent decreases of low-grade disease and absolute increases in intermediate and high-risk cancer. For any given age and PSA, propensity matching demonstrates more aggressive disease in the post-recommendation era.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.