ArticleInternational journal of colorectal disease2018
Increased risk of periodontitis among patients with Crohn's disease: a population-based matched-cohort study.
Article in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- A systematic review and network meta-analysis of the association between periodontitis and inflammatory bowel diseases.BMC oral health · 2025Pooled it
- The Potential Association Between Inflammatory Bowel Diseases and Apical Periodontitis: A Systematic Review and Meta-Analysis.European endodontic journal · 2024Pooled it
- Association between sleep-disordered breathing and periodontitis: a meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2023Pooled it
- Patients with inflammatory bowel disease have a higher chance of developing periodontitis: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Periodontitis and inflammatory bowel disease: a meta-analysis.BMC oral health · 2020Pooled it
- Ulcerative colitis-driven gut dysbiosis exacerbates periodontal bone loss through the gut-oral axis /Th17/Treg imbalance.NPJ biofilms and microbiomes · 2026Article
- Bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease: A systematic review and meta-analysis.The Japanese dental science review · 2025Review
- Unravelling the Oral-Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective.Journal of Crohn's & colitis · 2024Review
- Review
- Potential effects of specific gut microbiota on periodontal disease: a two-sample bidirectional Mendelian randomization study.Frontiers in microbiology · 2024Article
- Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization.Scientific reports · 2023Article
- Exploration of the shared gene signatures and molecular mechanisms between periodontitis and inflammatory bowel disease: evidence from transcriptome data.Gastroenterology report · 2023Article
- The effect of the "Oral-Gut" axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations.Frontiers in cellular and infection microbiology · 2023Review
- Periodontitis prevalence in patients with ulcerative colitis and Crohn's disease - PPCC: A case-control study.Journal of clinical periodontology · 2022Article
- Pathogenic associations between oral and gastrointestinal diseases.Trends in molecular medicine · 2022Review
- Evaluation of periodontal status and cytokine levels in saliva and gingival crevicular fluid of patients with inflammatory bowel diseases.Journal of periodontology · 2022Article
- Role of Interleukin-17A in the Pathomechanisms of Periodontitis and Related Systemic Chronic Inflammatory Diseases.Frontiers in immunology · 2022Review
- Neutrophils Orchestrate the Periodontal Pocket.Frontiers in immunology · 2021Review
- Co-pathogens in Periodontitis and Inflammatory Bowel Disease.Frontiers in medicine · 2021Review
- Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study.World journal of gastroenterology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundPeriodontitis is a frequently cited extraintestinal manifestation of Crohn's disease (CD). Despite a plethora of investigations and a recent meta-analysis linking CD and periodontitis, no study has estimated the risk of periodontitis among CD patients with respect to a comparison group nor has any investigation analyzed the effect of CD-specific medications on the risk of periodontitis. The present cohort study compared CD patients and matched subjects without a history of inflammatory bowel disease (IBD) to estimate the effect of CD and CD-specific pharmaceutical prescriptions on the risk of developing periodontitis by leveraging a population-based dataset in Taiwan.
methodsWe sourced 6657 CD patients and 26,628 comparison subjects without a history of IBD from the Taiwan National Health Insurance Database. Cox proportional hazards regressions were used to estimate the risk of subsequent periodontitis by CD status and pharmaceutical prescription during the follow-up period.
resultsAfter adjusting for socioeconomic status (SES), urbanicity, selected medical co-morbidities, and CD-specific pharmaceutical prescriptions, the hazard ratio (HR) for subsequent periodontitis among patients with CD was 1.36 (95% CI = 1.25-1.48) that of comparison subjects. There was not a significant difference in risk between genders or across ages. Steroids (95% CI = 0.66-0.77) appeared to confer a protective effect and Aspirin, Plavix, and Licodin were marginally protective (95% CI = 0.76-0.95).
conclusionThis is the first study to report an increased HR for subsequent periodontitis among CD patients when compared to matched comparison subjects without IBD. The protective effect of some pharmaceuticals may suggest that treatment of CD protects against periodontitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.