ArticleIntensive care medicine2018
Assessing predictive accuracy for outcomes of ventilator-associated events in an international cohort: the EUVAE study.
Article in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unravelling the complexity of ventilator-associated pneumonia: a systematic methodological literature review of diagnostic criteria and definitions used in clinical research.Critical care (London, England) · 2024Pooled it
- Impact of a national collaborative project to improve the care of mechanically ventilated patients.PloS one · 2023Trial
- Antimicrobial Resistance and Virulence ofAntibiotics (Basel, Switzerland) · 2026Article
- Comparative analysis of ventilator-associated pneumonia and ventilator-associated event surveillance systems: a retrospective observational study.Journal of Korean biological nursing science · 2026Article
- Phenotypic and Whole-Genome Sequencing-Based Profiling of Antimicrobial Resistance and Virulence inGenes · 2026Article
- Epidemiology of ventilator associated events in intubated patients: a multicenter observational study.BMC infectious diseases · 2025Observational
- Ventilator-associated pneumonia biomarker evaluation (VIBE) study: protocol for a prospective, observational, case-cohort study.BMJ open · 2025Article
- An Innovative Deep Learning Approach for Ventilator-Associated Pneumonia (VAP) Prediction in Intensive Care Units-Pneumonia Risk Evaluation and Diagnostic Intelligence via Computational Technology (PREDICT).Journal of clinical medicine · 2025Article
- Incidence and clinical outcomes of ventilator-associated events in Russian tertiary care settings: an analysis of electronic health records.BMC research notes · 2025Article
- An interpretable machine learning model for predicting in-hospital mortality in ICU patients with ventilator-associated pneumonia.PloS one · 2025Article
- Association between anion gap and the 30-day mortality of patients with ventilator-associated pneumonia: a study of the MIMIC-III database.Journal of thoracic disease · 2024Article
- Prevention of ventilator-associated pneumonia through care bundles: A systematic review and meta-analysis.Journal of intensive medicine · 2023Article
- Ventilator-associated events: From surveillance to optimizing management.Journal of intensive medicine · 2023Review
- Relationship between ventilator bundle compliance and the occurrence of ventilator-associated events: a prospective cohort study.BMC nursing · 2022Article
- Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update.Infection control and hospital epidemiology · 2022Article
- Effective Implementation of Ventilator Care Bundles in Improves Outcomes: A Multicenter Randomized Controlled Clinical Trial.Critical care explorations · 2021Article
- Ventilator-Associated Pneumonia in COVID-19 Patients: A Retrospective Cohort Study.Antibiotics (Basel, Switzerland) · 2021Article
- A comparison of diagnostic algorithms and clinical parameters to diagnose ventilator-associated pneumonia: a prospective observational study.BMC pulmonary medicine · 2021Observational
- The epidemiology and clinical outcomes of ventilator-associated events among 20,769 mechanically ventilated patients at intensive care units: an observational study.Critical care (London, England) · 2021Observational
- Usefulness of Sepsis-3 in diagnosing and predicting mortality of ventilator-associated lower respiratory tract infections.PloS one · 2021Article
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Authors and funding
13 authors.
Funding
Abstract
purposeTo analyze the impact on patient outcome of ventilator-associated events (VAEs) as defined by the Centers for Disease Control and Prevention (CDC) in 2008, 2013, and the correlation with ventilator-associated pneumonia (VAP) or tracheobronchitis (VAT).
methodsThis was a prospective, observational, multicenter, international study conducted at 13 intensive care units (ICUs); thirty consecutive adults mechanically ventilated for ≥ 48 h per site were eligible, with daily follow-up being recorded in a collaborative web database; VAEs were assessed using the 2013 CDC classification and its 2015 update.
resultsA total of 2856 ventilator days in 244 patients were analyzed, identifying 33 VAP and 51 VAT episodes; 30-day ICU mortality was significantly higher (42.8 vs. 19.6%, p < 0.007) in patients with VAP than in those with VAT. According to the 2013 CDC definitions, 117 VAEs were identified: 113 (96%) were infection-related ventilator-associated complication-plus (IVAC-plus), while possible ventilator-associated pneumonia (PVAP) was found in 64 (56.6%) of them. VAE increased the number of ventilator days and prolonged ICU and hospital LOS (by 5, 11, and 12 days, respectively), with a trend towards increased 30-day mortality (43 vs 28%, p = 0.06). Most episodes (26, 55%) classified as IVAC-plus without PVAP criteria were due to atelectasis. PVAP significantly increased (p < 0.05) ventilator days as well as ICU and hospital LOS (by 10.5, 14, and 13 days, respectively). Only 24 (72.7%) of VAP and 15 (29.4%) of VAT episodes met IVAC-plus criteria.
conclusionsRespiratory infections (mainly VAT) were the most common complication. VAE algorithms only identified events with surrogates of severe oxygenation deterioration. As a consequence, IVAC definitions missed one fourth of the episodes of VAP and three fourths of the episodes of VAT. Identifying VAT (often missed by IVAC-plus criteria) is important, as VAP and VAT have different impacts on mortality.
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