ArticleJAMA otolaryngology-- head & neck surgery2018
Association of Tinnitus and Other Cochlear Disorders With a History of Migraines.
Article in JAMA otolaryngology-- head & neck surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Low Evidence for Tinnitus Risk Factors: A Systematic Review and Meta-analysis.Journal of the Association for Research in Otolaryngology : JARO · 2023Pooled it
- Optimal Dosing of Nortriptyline-Topiramate and Verapamil-Paroxetine Combinations in Tinnitus Treatment.The Laryngoscope · 2025Trial
- [Efficacy analysis of anti-migraine therapy for acute low-frequency hearing loss and investigation of its mechanisms].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Trial
- Efficacy of Nortriptyline-Topiramate and Verapamil-Paroxetine in Tinnitus Management: A Randomized Placebo-Controlled Trial.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Trial
- Caloric-vHIT Dissociation in Vestibular Migraine: An Observational, Retrospective Case Series Study.Journal of clinical medicine · 2026Article
- Migraine and auditory dysfunction: beyond comorbidity.Journal of neurology · 2026Review
- Associations Between Football-Related Exposures, Head Injury, Tinnitus, and Neuropsychological Health Outcomes Among Professional American-Style Football Players.Sports medicine - open · 2026Article
- Association between headache and hearing impairment in middle-aged and older adults in China health and retirement longitudinal study.Scientific reports · 2026Article
- Migraine impairs the auditory protective mechanism: a potential biomarker.The journal of headache and pain · 2026Article
- Tinnitus.Nature reviews. Disease primers · 2026Review
- Potential therapeutic role of calcitonin gene-related peptide medications for tinnitus.Journal of the Chinese Medical Association : JCMA · 2026Review
- Expanding the Spectrum of Central Sensitivity Syndrome: Integrating Otologic Migraine as Otologic Central Sensitivity Syndrome.Brain sciences · 2026Review
- Migraine-induced cochlear injury triggers ZBP1-mediated PANoptosis via CGRP signaling.The journal of headache and pain · 2026Article
- Article
- Vestibular migraine: course of symptoms during a four-year follow-up.Frontiers in neurology · 2025Article
- Beyond Vertigo: Vestibular, Aural, and Perceptual Symptoms in Vestibular Migraine.Current pain and headache reports · 2024Review
- Evaluation of Cochlear Symptoms in Migraine Patients without Vestibular Migraine and/or Ménière's Disease.Audiology research · 2023Article
- Comparison of clinical features in patients with vestibular migraine and migraine.Journal of neurology · 2023Article
- A proposed association between subjective nonpulsatile tinnitus and migraine.World journal of otorhinolaryngology - head and neck surgery · 2023Review
- Association between Otosclerosis and Rubella in Taiwan: A Nationwide Case-Control Study.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: A headache is a symptom of a migraine, but not all patients with migraine have headaches. It is still unclear whether a migraine might increase the risk of cochlear disorders, even though a migraine does not occur concurrently with cochlear disorders. Objective: To investigate the risk of cochlear disorders for patients with a history of migraines. Design, Setting, and Participants: This study used claims data from the Taiwan Longitudinal Health Insurance Database 2005 to identify 1056 patients with migraines diagnosed between January 1, 1996, and December 31, 2012. A total of 4224 controls were also identified from the same database based on propensity score matching. Statistical analysis was performed from January 23, 1996, to December 28, 2012. Main Outcomes and Measures: The incidence rate of cochlear disorders (tinnitus, sensorineural hearing impairment, and/or sudden deafness) was compared between the cohorts by use of the Kaplan-Meier method. The Cox proportional hazards regression model was also used to examine the association of cochlear disorders with migraines. Results: Of the 1056 patients with migraines, 672 were women and 384 were men, and the mean (SD) age was 36.7 (15.3) years. Compared with the nonmigraine cohort, the crude hazard ratio for cochlear disorders in the migraine cohort was 2.83 (95% CI, 2.01-3.99), and the adjusted hazard ratio was 2.71 (95% CI, 1.86-3.93). The incidence rates of cochlear disorders were 81.4 (95% CI, 81.1-81.8) per 1 million person-years for the migraine cohort and 29.4 (95% CI, 29.2-29.7) per 1 million person-years for the nonmigraine cohort. The cumulative incidence of cochlear disorders in the migraine cohort (12.2%) was significantly higher than that in the matched nonmigraine cohort (5.5%). Subgroup analysis showed that, compared with the nonmigraine cohort, the adjusted hazard ratios in the migraine cohort were 3.30 (95% CI, 2.17-5.00) for tinnitus, 1.03 (95% CI, 0.17-6.41) for sensorineural hearing impairment, and 1.22 (95% CI, 0.53-2.83) for sudden deafness. Conclusions and Relevance: In this population-based study, the risk of cochlear disorders, especially for tinnitus, was found to be significantly higher among patients with a history of migraines. This finding may support the presence and/or concept of "cochlear migraine."
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