ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018
Apraxia profiles-A single cognitive marker to discriminate all variants of frontotemporal lobar degeneration and Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Executive functions in primary progressive aphasia: A meta-analysis.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Pooled it
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Assessing Limb Apraxia in Quebec: Normative Study of the Brief Battery for the Evaluation of Praxis in Healthy French-Speaking Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Apraxic deficits predict general cognitive impairment in patients with biomarker-verified Alzheimer's pathology.Journal of neurology · 2025Article
- Cortical Tau Aggregation Patterns Associated With Apraxia in Patients With Alzheimer Disease.Neurology · 2024Article
- Apraxia phenotypes and frontotemporal lobar degeneration.Journal of neurology · 2024Article
- Apraxia Patterns for the Differentiation between Alzheimer's Disease and Frontotemporal Dementia Variants.Medicina (Kaunas, Lithuania) · 2024Article
- Affection of Motor Network Regions by Tau Pathology Across the Alzheimer's Disease Spectrum.eNeuro · 2024Article
- Differences and Similarities in Empathy Deficit and Its Neural Basis between Logopenic and Amnesic Alzheimer's Disease.Journal of personalized medicine · 2023Article
- Impaired Affordance Perception as the Basis of Tool Use Deficiency in Alzheimer's Disease.Healthcare (Basel, Switzerland) · 2022Article
- Multidimensional Clinical Assessment in Frontotemporal Dementia and Its Spectrum in Latin America and the Caribbean: A Narrative Review and a Glance at Future Challenges.Frontiers in neurology · 2021Review
- The Electrophysiological Correlates of Phoneme Perception in Primary Progressive Aphasia: A Preliminary Case Series.Frontiers in human neuroscience · 2021Article
- Bimanual Gesture Imitation Links to Cognition and Olfaction.Journal of the American Geriatrics Society · 2019Article
- Psychological and Cognitive Markers of Behavioral Variant Frontotemporal Dementia-A Clinical Neuropsychologist's View on Diagnostic Criteria and Beyond.Frontiers in neurology · 2019Review
- Application of Functional Near-Infrared Spectroscopy in Apraxia Studies in Alzheimer's Disease: A Proof of Concept Experiment.Journal of medical signals and sensorsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionApraxia is common in neurodegenerative dementias but underrepresented in clinical workup for differential diagnoses.
methodsPraxis-profiles were assessed with the Dementia Apraxia Test in 93 patients with early stages of biologically supported Alzheimer's disease or frontotemporal lobar degeneration: semantic primary-progressive aphasia, nonfluent primary-progressive aphasia, and behavioral variant frontotemporal dementia. Associations with core cognitive deficits of the dementia subtypes (i.e., visuospatial, sociocognitive, and semantic-linguistic) were explored.
resultsPatients showed significant apraxia compared with healthy controls but also disease-specific praxis-profiles. Using only the Dementia Apraxia Test, all four dementia subtypes could be correctly discriminated in 64.4% of cases, and in 78.2% when only distinguishing Alzheimer's disease versus frontotemporal lobar degeneration. Praxis-profiles showed consistent associations with core cognitive impairments of the different dementia subtypes. DISCUSSION: The Dementia Apraxia Test is a valid, time-efficient and versatile cognitive marker to delineate variants of frontotemporal lobar degeneration and Alzheimer's disease in clinical routine, facilitating differential diagnoses of dementia subtypes in early disease stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.