Evidence map›Paper›PMID 30003066›Full record

ArticleJournal of cancer prevention2018

Comparative Analysis of Ileal and Cecal Microbiota in Aged Rats.

Sun Min Lee, Nayoung Kim, Ji Hyun Park, Ryoung Hee Nam, Kichul Yoon, Dong Ho Lee

Open access · diamondAbstract read
In one paragraph

Article in Journal of cancer prevention, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. The Effect ofJournal of neurogastroenterology and motility · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  8. Article
  9. Roles of Sex Hormones and Gender in the Gut Microbiota.Journal of neurogastroenterology and motility · 2021
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Nutrients · 2019
    Article
  18. Article
  19. The Effect of Microbiota on Colon Carcinogenesis.Journal of cancer prevention · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sun Min LeeDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Nayoung KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Ji Hyun ParkDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Ryoung Hee NamDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Kichul YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Dong Ho LeeDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Seoul National University Bundang Hospital · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGut microbiota contributes to intestinal and immune homeostasis through host-microbiota interactions. Distribution of the gut microbiota differs according to the location in the gastrointestinal tract. Although the microbiota properties change with age, evidence for the regional difference of gut microbiota has been restricted to the young. The aim of this study is to compare the gut microbiota between terminal ileum and cecum of old rats.

methodsWe analyzed gut microbiome of luminal contents from ileum and cecum of 74-week-old and 2-year-old rats (corresponding to 60-year and 80-year-old of human age) by metagenome sequencing of 16S rRNA.

resultsInter-individual variation (beta diversity) of microbiota was higher in ileum than in cecum. Conversely, alpha diversity of microbiota composition was higher in cecum than in ileum.

conclusionsMajor regional distinctions of microbiota between ileum and cecum of old rats appear consistent with those of young rats. Age-related alterations of gut microbiota in old rats seem to occur in minor compositions.

Indexed as

AgingCecumGastrointestinal microbiomeIleumRats

Identifiers

PMID30003066
PMCPMC6037205
OpenAlexW2835976349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.