ArticleJournal of ophthalmology2018
Psychological Aspects and Depression in Patients with Symptomatic Keratoconus.
Article in Journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Depression and Anxiety in Patients With Irreversible Vision Loss: Meta-Analysis and Systematic Review.International journal of psychiatry in medicine · 2026Pooled it
- Beyond Vision: Unveiling the Psychiatric Dimensions of Keratoconus.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Depression among keratoconus patients: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Functional and Emotional Impact of Dry Eye and Meibomian Gland Dysfunction in Keratoconus.Biomedicines · 2025Article
- Keratoconus: The Local Manifestation of a Systemic Disease?Journal of clinical medicine · 2025Review
- Socioeconomic and Demographic Disparities in Keratoconus Treatment.American journal of ophthalmology · 2025Article
- The association of symptomatic vitreous floaters with depression and anxiety.International ophthalmology · 2024Article
- Opportunities for Improving the Long-term Management of Keratoconus Patients.Journal of contact lens research & science · 2024Article
- Impact of the COVID-19 Pandemic on Mental Health among Patients with Chronic Ocular Conditions.Vision (Basel, Switzerland) · 2023Article
- One-year outcomes of resveratrol supplement with aflibercept versus aflibercept monotherapy in wet age-related macular degeneration.International journal of ophthalmology · 2023Article
- Evaluation of Personality Features and Mental State of Keratoconus Patients.Beyoglu eye journal · 2021Article
- Article
- Both sub-scales of the "Keratoconus End-Points Assessment Questionnaire" (KEPAQ) are unidimensional and reliable.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Both Subjective Emotional Distress and Visual Handicap Correlate with Belin ABCD Classification in the Worse Eye as Measured with the "Keratoconus End-Points Assessment Questionnaire" (KEPAQ).Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Development and Validation of the "Keratoconus End-Points Assessment Questionnaire" (KEPAQ), a Disease-Specific Instrument for Evaluating Subjective Emotional Distress and Visual Function Through Rasch Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Keratoconus: A historical and prospective review.Oman journal of ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the psychological status of keratoconus sufferers and to determine the relationship between depression and visual impairment in this group of patients.
methodsFifty-six patients with keratoconus and forty-seven age- and gender-matched healthy control subjects were retroprospectively analyzed. Every participant underwent a complete ophthalmological examination. Keratoconus diagnosis was confirmed with corneal topography and tomography. Zung Depression Inventory Questionnaire and Patient Health Questionnaire-9 (PHQ-9) were completed by everyone.
resultsVisual acuity (logMAR 0.53 ±0.30 versus 0.11 ± 0.16), PHQ-9 score (10.20 ± 4.00 versus 5.40 ± 5.01), and Zung score (46.52 ± 8.70 versus 38.53 ± 8.41) showed a statistically significant difference between keratoconus patients and healthy controls (
conclusionDepressive disorders appear to be directly associated with keratoconus, both in frequency and intensity. Worse visual acuity and older age could be identified as predictive factors for their emotional status. Moreover, the disease itself could be recognized as an independent risk factor for depression development, underlying the need for close monitoring and supportive management. To the best of our knowledge, our study is the first in the literature to elaborate the association between keratoconus and depression, by assessing two different questionnaires simultaneously.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.