Evidence map›Paper›PMID 30002734›Full record

ArticleDiabetology & metabolic syndrome2018

Association of adiponectin with cognitive function precedes overt diabetes in the Brazilian Longitudinal Study of Adult Health: ELSA.

Adriana Cezaretto, Claudia Kimie Suemoto, Isabela Bensenor, Paulo A Lotufo, Bianca de Almeida-Pititto, Sandra R G Ferreira, ELSA Research Group

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Article in Diabetology & metabolic syndrome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

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0cells of the map it votes in
11citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Adriana Cezaretto1Department of Epidemiology, School of Public Health, University of Sao Paulo, São Paulo, Brazil.
Claudia Kimie Suemoto2Division of Geriatrics, Medical School, University of Sao Paulo, São Paulo, Brazil.
Isabela Bensenor3Department of Internal Medicine, Medical School, University of Sao Paulo, São Paulo, Brazil.
Paulo A Lotufo3Department of Internal Medicine, Medical School, University of Sao Paulo, São Paulo, Brazil.
Bianca de Almeida-Pititto1Department of Epidemiology, School of Public Health, University of Sao Paulo, São Paulo, Brazil.
Sandra R G Ferreira1Department of Epidemiology, School of Public Health, University of Sao Paulo, São Paulo, Brazil.
ELSA Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdiponectin is an insulin-sensitizer adipocytokine endowed with neuroprotective actions. Whether adiponectin regulates neuronal functioning toward delaying cognitive decline independently of the glucose metabolism disturbance has been poorly explored. This study evaluated if the performance in cognitive tests was associated with adiponectin levels prior the development of type 2 diabetes in middle-aged individuals.

methodsA sample of 938 non-diabetic participants of ELSA had their cognitive function assessed by the CERAD delayed word recall test, the verbal fluency test and the trail making test. Stepwise multiple linear regression using forward selection had the response to cognitive tests as the dependent variable and adiponectin as the independent variable of main interest, adjusted for glucose tolerance status and confounders.

resultsMean age was 45.7 ± 4.9 years, 54.5% were women, 43.0% had high education level, 59.3% weight excess and 70.0% prediabetes. In crude model, only the delayed recall memory was associated with adiponectin levels. In an initial regression model, delayed recall memory remained independently associated with adiponectin levels and prediabetes. After complete adjustments, adiponectin but not prediabetes maintained independently associated with delayed recall memory (β 0.067; 95% CI 0.006-0.234; p = 0.040). On the other hand, learning memory showed to be associated with prediabetes (β 0.71 95% CI 0.17; 1.24; p = 0.009) but not with adiponectin.

conclusionsThe association of memory with adiponectin in middle-aged individuals, prior overt diabetes, suggests that this adipocytokine could anticipate cognitive impairmentρ detection, when preventive strategies could be more effectively implemented. The usefulness of adiponectin to identify increased risk for cognitive dysfunction before advanced age needs to be prospectively investigated in ELSA cohort.

Indexed as

AdiponectinCognitive functionDementiaPrediabetesPrevention

Identifiers

PMID30002734
PMCPMC6038247

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