ArticleEvidence-based complementary and alternative medicine : eCAM2018
A Pilot Study on Characteristics of Metabolomics and Lipidomics according to Sasang Constitution.
Article in Evidence-based complementary and alternative medicine : eCAM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Beneficial Effects of a Low-Glycemic Diet on Serum Metabolites and Gut Microbiota in Obese Women WithFrontiers in nutrition · 2022Article
- Investigating the Biomarkers of the Sasang Constitution via Network Pharmacology Approach.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Comparative gut microbiome analysis of the3 Biotech · 2020Article
- Nutrikinetic study of fermented soybean paste (Nutrition research and practice · 2020Article
- Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS andEvidence-based complementary and alternative medicine : eCAM · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
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Abstract
Although classification of an individual's Sasang constitution is a key step in the prescription of traditional Korean medicine, the classifying process is complex and not objective. Identification of metabolic-based biomarkers could allow the development of a reliable and sensitive classification technique and even therapeutic management. Our pilot study investigated whether metabolites in plasma are characteristic of Sasang constitutions. Ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolic analysis was conducted against 15 Soyangin (SY), 15 Taeeumin (TE), and 18 Soeumin (SE) individuals, as classified according to the Questionnaire for Sasang Constitution Classification II (QSCC II) and specialist diagnosis. Metabolomics data showed that the TE group was significantly separated from the SY and SE groups. Nine canonical pathways related to constitution; phenylalanine metabolism, aminoacyl-tRNA, tyrosine, and tryptophan biosynthesis were activated in the TE group as compared with the other groups. Similar to the results of the metabolomics analysis, the TE group was also significantly separated from the other two groups by lipidomic analysis. On the other hand, the intensity of lipid metabolites was higher in the SY group than in the other groups. Our findings suggest that the combined analysis of metabolomics and lipidomics can provide useful information for characteristics of Sasang constitutions.
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