ArticleScientific reports2018
Whole genome sequencing and phylogenetic analysis of strains of the agent of Lyme disease Borrelia burgdorferi from Canadian emergence zones.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Reply to the letter regarding 'Unravelling the genomic landscape of CanadianMicrobial genomics · 2026Article
- Letter regarding unravelling the genomic landscape of CanadianMicrobial genomics · 2026Article
- Lyme borreliosis.Nature reviews. Disease primers · 2026Review
- Unravelling the genomic landscape of CanadianMicrobial genomics · 2026Article
- Comparative analysis of Borrelia's Defence mechanisms and their impact on genetic manipulation of low-passage isolates ofCurrent research in microbial sciences · 2026Article
- Polyvalent mRNA vaccine targeting outer surface protein C affords multi-strain protection against Lyme disease.NPJ vaccines · 2025Article
- Genetic landscape of Borrelia burgdorferi sensu stricto in Canada: a study of genetic diversity.Scientific reports · 2025Article
- Article
- Article
- Historical Summary of Tick and Animal Surveillance Studies for Lyme Disease in Canada, 1975-2023: A Scoping Review.Zoonoses and public health · 2025Article
- Complex exchanges among plasmids and clonal expansion of lineages shape the population structure and virulence ofbioRxiv : the preprint server for biology · 2025Article
- A core genome MLST scheme for Borrelia burgdorferi sensu lato improves insights into the evolutionary history of the species complex.Cell reports methods · 2025Article
- Adaptive immunity inApplied and environmental microbiology · 2024Article
- Article
- Whole-genome sequencing of Western CanadianMicrobial genomics · 2024Article
- Diversity and host specificity ofInfection and immunity · 2024Article
- Case report of disseminated borrelial lymphocytoma with isolation ofFrontiers in medicine · 2024Article
- Variation among strains of Borrelia burgdorferi in host tissue abundance and lifetime transmission determine the population strain structure in nature.PLoS pathogens · 2023Article
- Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination.PLoS pathogens · 2023Article
- A high fidelity approach to assembling the complex Borrelia genome.BMC genomics · 2023Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lyme disease is emerging in southern Canada due to range expansion of the tick vector, followed by invasion of the agent of Lyme disease Borrelia burgdorferi sensu stricto. Strain diversity, as determined by Multi Locus Sequence Typing, occurs in this zone of emergence, and this may have its origins in adaptation to ecological niches, and have phenotypic consequences for pathogenicity and serological test performance. Sixty-four unique strains were cultured from ticks collected in southern Canada and the genomes sequenced using the Illumina MiSeq platform. A maximum likelihood phylogenetic tree of the chromosome revealed two large clades with multiple subclades. Consistent with previous studies on this species, the clades were not geographically defined, and some Canadian strains were highly divergent from previously sequenced US strains. There was evidence for recombination in the chromosome but this did not affect the phylogeny. Analysis of chromosomal genes indicated that these are under intense purifying selection. Phylogenies of the accessory genome and chromosome were congruent. Therefore strain differences identified in the phylogeny of chromosomal genes likely act as a proxy for genetic determinants of phenotypic differences amongst strains that are harboured in the accessory genome. Further studies on health implications of strain diversity are needed.
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