ArticleNature communications2018
Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Inheritance entropy: A model-independent method to probe the hereditary structure of cell lineage trees.PRX life · 2026Article
- DeepKymoTracker: A tool for accurate construction of cell lineage trees for highly motile cells.PloS one · 2025Article
- Single-cell multi-omics and lineage tracing to dissect cell fate decision-making.Stem cell reports · 2023Review
- PU.1 is required to restrain myelopoiesis during chronic inflammatory stress.Frontiers in cell and developmental biology · 2023Article
- Combining single-cell tracking and omics improves blood stem cell fate regulator identification.Blood · 2022Article
- Heritable changes in division speed accompany the diversification of single T cell fate.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.The Journal of experimental medicine · 2022Article
- Mechanistic models of blood cell fate decisions in the era of single-cell data.Current opinion in systems biology · 2021Review
- Analyzing signaling activity and function in hematopoietic cells.The Journal of experimental medicine · 2021Review
- Computational modeling of stem and progenitor cell kinetics identifies plausible hematopoietic lineage hierarchies.iScience · 2021Article
- Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies.Experimental hematology · 2020Review
- Probing pluripotency gene regulatory networks with quantitative live cell imaging.Computational and structural biotechnology journal · 2020Review
- GATA2 and PU.1 Collaborate To Activate the Expression of the MouseMolecular and cellular biology · 2019Article
- Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.Immunity · 2019Article
- Maps of variability in cell lineage trees.PLoS computational biology · 2019Article
- Modeling the Hematopoietic Landscape.Frontiers in cell and developmental biology · 2019Review
- Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages.Nature communications · 2018Article
- Reprogramming multistable monotone systems with application to cell fate control.IEEE transactions on network science and engineeringArticle
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Authors and funding
7 authors.
Funding
Abstract
Molecular regulation of cell fate decisions underlies health and disease. To identify molecules that are active or regulated during a decision, and not before or after, the decision time point is crucial. However, cell fate markers are usually delayed and the time of decision therefore unknown. Fortunately, dividing cells induce temporal correlations in their progeny, which allow for retrospective inference of the decision time point. We present a computational method to infer decision time points from correlated marker signals in genealogies and apply it to differentiating hematopoietic stem cells. We find that myeloid lineage decisions happen generations before lineage marker onsets. Inferred decision time points are in agreement with data from colony assay experiments. The levels of the myeloid transcription factor PU.1 do not change during, but long after the predicted lineage decision event, indicating that the PU.1/GATA1 toggle switch paradigm cannot explain the initiation of early myeloid lineage choice.
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Registered trials
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