ArticleMaterials (Basel, Switzerland)2018
Carbonate Apatite Containing Statin Enhances Bone Formation in Healing Incisal Extraction Sockets in Rats.
Article in Materials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- A systematic review of a novel alloplast carbonate apatite granules.Frontiers in dental medicine · 2024Pooled it
- Prevalence and Risk Factors of Oral Lesions in a Portuguese Subpopulation: A Retrospective Study.Journal of clinical medicine · 2025Article
- Efficacy of statins in tissue healing following tooth extraction: a systematic review of animal studies.Annals of translational medicine · 2025Review
- Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems.ACS biomaterials science & engineering · 2023Review
- Alveolar Bone Preservation Using a Combination of Nanocrystalline Hydroxyapatite and Injectable Platelet-Rich Fibrin: A Study in Rats.Current issues in molecular biology · 2023Article
- Preparation and Characterization of PLG Microparticles by the Multiple Emulsion Method for the Sustained Release of Proteins.Micromachines · 2022Article
- Effects of Super-Activated Platelet Lysate on Early Healing of Tooth Extraction Sockets in Rats.Drug design, development and therapy · 2022Article
- The effects of statins on dental and oral health: a review of preclinical and clinical studies.Journal of translational medicine · 2020Review
- Special Issue: Novel Advances and Approaches in Biomedical Materials Based on Calcium Phosphates.Materials (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to evaluate the feasibility of using apatite blocks fabricated by a dissolution⁻precipitation reaction of preset gypsum, with or without statin, to enhance bone formation during socket healing after tooth extraction. Preset gypsum blocks were immersed in a Na₃PO₄ aqueous solution to make hydroxyapatite (HA) low crystalline and HA containing statin (HAFS), or in a mixed solution of Na₂HPO₄ and NaHCO₃ to make carbonate apatite (CO) and CO containing statin (COFS). The right mandibular incisors of four-week-old male Wistar rats were extracted and the sockets were filled with one of the bone substitutes or left untreated as a control (C). The animals were sacrificed at two and four weeks. Areas in the healing socket were evaluated by micro-computed tomography (micro-CT) and histological analyses. The bone volume, trabecular thickness, and trabecular separation were greatest in the COFS group, followed by the CO, HAFS, HA, and C groups. The bone mineral density of the COFS group was greater than that of the other groups when evaluated in the vertical plane. The results of this study suggest that COFS not only allowed, but also promoted, bone healing in the socket. This finding could be applicable for alveolar bone preservation after tooth extraction.
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