ArticleJournal of cell science2018
Primary cilia are necessary for Prx1-expressing cells to contribute to postnatal skeletogenesis.
Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- An ex vivo appositional growth model to study periosteal activity and associated BMP signaling.JBMR plus · 2026Article
- Overactivation of EGFR signaling in skeletal stem/progenitor cells promotes bone formation and repair.Theranostics · 2025Article
- Reciprocal negative feedback between Prrx1 and miR-140-3p regulates rapid chondrogenesis in the regenerating antler.Cellular & molecular biology letters · 2024Article
- Primary cilia support cartilage regeneration after injury.International journal of oral science · 2023Article
- The role of PRX1-expressing cells in periodontal regeneration and wound healing.Frontiers in physiology · 2023Review
- A periosteum-derived cell line to study the role of BMP/TGFβ signaling in periosteal cell behavior and function.Frontiers in physiology · 2023Article
- Primary Cilia: The New Face of Craniofacial Research.Biomolecules · 2022Review
- Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.Nature communications · 2022Article
- Progress of Periosteal Osteogenesis: The Prospect of In Vivo Bioreactor.Orthopaedic surgery · 2022Review
- Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling.BMC developmental biology · 2021Article
- Low-Dose Tamoxifen Induces Significant Bone Formation in Mice.JBMR plus · 2021Article
- Article
- Recent Advances in Single-Cell View of Mesenchymal Stem Cell in Osteogenesis.Frontiers in cell and developmental biology · 2021Review
- Markers for Identification of Postnatal Skeletal Stem Cells In Vivo.Current osteoporosis reports · 2020Review
- COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1.Scientific reports · 2020Article
- Loss of Adenylyl Cyclase 6 in Leptin Receptor-Expressing Stromal Cells Attenuates Loading-Induced Endosteal Bone Formation.JBMR plus · 2020Article
- Article
- Primary cilia as the nexus of biophysical and hedgehog signaling at the tendon enthesis.Science advances · 2020Article
- The Role of IFT140 in Osteogenesis of Adult Mice Long Bone.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- TheBiology open · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although Prx1 (also known as PRRX1)-expressing cells and their primary cilia are critical for embryonic development, they have yet to be studied in the context of postnatal skeletogenesis owing to the lethality of mouse models. A tamoxifen-inducible Prx1 model has been developed, and we determined that expression directed by this promoter is highly restricted to the cambium layers in the periosteum and perichondrium after birth. To determine the postnatal role of these cambium layer osteochondroprogenitors (CLOPs) and their primary cilia, we developed models to track the fate of CLOPs (Prx1CreER-GFP;Rosa26
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.