Evidence map›Paper›PMID 30002134›Full record

ArticleDiabetes2018

miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity.

Eun-Hee Koh, Natasha Chernis, Pradip K Saha, Liuling Xiao, David A Bader, Bokai Zhu, Kimal Rajapakshe, Mark P Hamilton, Xia Liu, Dimuthu Perera and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

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  6. AdipocyteeLife · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 4 countries.

Eun-Hee KohDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Natasha ChernisDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Pradip K SahaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Liuling XiaoCenter for Bioenergetics, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX.
David A BaderDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Bokai ZhuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Kimal RajapaksheDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Mark P HamiltonDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Xia LiuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Dimuthu PereraDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Xi ChenDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Brian YorkDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Michael TraunerHans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Cristian CoarfaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Mandeep BajajDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX.
David D MooreDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Tuo DengCenter for Bioenergetics, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX.
Sean E McGuireDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Sean M HartigDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX hartig@bcm.edu.ORCID 0000-0002-2695-2072
Baylor College of Medicine · USHouston Methodist · USMedical University of Vienna · ATThe University of Texas MD Anderson Cancer Center · USUlsan College · KR

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Diabetes Endocrinology Research CenterP30DK079638 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHAN, LAWRENCE · 2008 to 2012
$6.4M
METABOLIC IMPACTS OF TYPE II INTERFERON SIGNALS IN OBESITYR01DK114356 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2017 to 2025
$4.6M
T cell co-stimulation in obesity-induced adipose inflammationR01DK110184 · NIDDK · METHODIST HOSPITAL RESEARCH INSTITUTE · PI DENG, TUO · 2017 to 2018
$805k
A novel axis regulates adipocyte plasticityK01DK096093 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2013 to 2015
$444k
The Role of Mitochondrial Heterogeneity in Pyruvate Flux in Prostate Cancer ProgressionR21CA205257 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MCGUIRE, SEAN E · 2016 to 2017
$379k
Transcriptional regulation by the CaMKK2/AMPK/SRC-3 signaling pathway in NAFLDR56DK113024 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI YORK, BRIAN · 2017 to 2017
$233k
Regulation of SYSTEMIC INSULIN SENSITIVITY by miRNA-30aR03DK105006 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2016 to 2017
$159k
Functional Investigation of the Mitochondrial Pyruvate Carrier in Prostate CancerF30CA196108 · NCI · BAYLOR COLLEGE OF MEDICINE · PI BADER, DAVID ALAN · 2015 to 2017
$123k
NCI NIH HHS F30 CA196108NCI NIH HHS R21 CA205257NIDDK NIH HHS K01 DK096093NIDDK NIH HHS P30 DK056338NIDDK NIH HHS P30 DK079638NIDDK NIH HHS R01 DK110184NIDDK NIH HHS R01 DK114356NIDDK NIH HHS R03 DK105006NIDDK NIH HHS R56 DK113024
6 · The paper itself

Abstract

Chronic inflammation accompanies obesity and limits subcutaneous white adipose tissue (WAT) expandability, accelerating the development of insulin resistance and type 2 diabetes mellitus. MicroRNAs (miRNAs) influence expression of many metabolic genes in fat cells, but physiological roles in WAT remain poorly characterized. Here, we report that expression of the miRNA

Indexed as

Adipose Tissue, WhiteAnimalsDiabetes Mellitus, Type 2Diet, High-FatEnergy MetabolismInsulin ResistanceLiverMiceMicroRNAsObesitySTAT1 Transcription FactorSubcutaneous FatMicroRNAsMIRN30a microRNA, mouseStat1 protein, mouseSTAT1 Transcription Factor

Identifiers

PMID30002134
PMCPMC6245225
OpenAlexW2834915452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.