Evidence map›Paper›PMID 30002081›Full record

ArticleGenetics2018

Relationship Between Sequence Homology, Genome Architecture, and Meiotic Behavior of the Sex Chromosomes in North American Voles.

Beth L Dumont, Christina L Williams, Bee Ling Ng, Valerie Horncastle, Carol L Chambers, Lisa A McGraw, David Adams, Trudy F C Mackay, Matthew Breen

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Beth L DumontInitiative in Biological Complexity, North Carolina State University, Raleigh, North Carolina 04609 beth.dumont@jax.org.ORCID 0000-0003-0918-0389
Christina L WilliamsDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 04609.
Bee Ling NgCytometry Core Facility, Wellcome Sanger Institute, Hinxton, United Kingdom, CB10 1SA.
Valerie HorncastleSchool of Forestry, Northern Arizona University, Flagstaff, Arizona 86011.
Carol L ChambersSchool of Forestry, Northern Arizona University, Flagstaff, Arizona 86011.
Lisa A McGrawDepartment of Biological Sciences, North Carolina State University, Raleigh, North Carolina 04609.
David AdamsCytometry Core Facility, Wellcome Sanger Institute, Hinxton, United Kingdom, CB10 1SA.
Trudy F C MackayInitiative in Biological Complexity, North Carolina State University, Raleigh, North Carolina 04609.
Matthew BreenDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 04609.
North Carolina State University · USNorthern Arizona University · USWellcome Sanger Institute · GB

Funding

Mechanisms of Recurrent, Parallel Loss of X/Y Pairing and Recombination at Meiosis in VolesR00GM110332 · NIGMS · JACKSON LABORATORY · PI DUMONT, BETHANY L · 2017 to 2019
$746k
Mechanisms of Recurrent, Parallel Loss of X/Y Pairing and Recombination at MeiosiK99GM110332 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI DUMONT, BETHANY L · 2014 to 2015
$164k
NIGMS NIH HHS K99 GM110332NIGMS NIH HHS R00 GM110332
6 · The paper itself

Abstract

In most mammals, the X and Y chromosomes synapse and recombine along a conserved region of homology known as the pseudoautosomal region (PAR). These homology-driven interactions are required for meiotic progression and are essential for male fertility. Although the PAR fulfills key meiotic functions in most mammals, several exceptional species lack PAR-mediated sex chromosome associations at meiosis. Here, we leveraged the natural variation in meiotic sex chromosome programs present in North American voles (

Indexed as

AnimalsArvicolinaeChromosome SegregationGenomicsMeiosisNorth AmericaPseudoautosomal RegionsSequence Analysis, DNASequence Homology, Nucleic AcidSex ChromosomesTelomereTelomere-Binding ProteinsX ChromosomeY ChromosomeTelomere-Binding Proteinsmeiotic synapsisMicrotus heterochromatinpseudoautosomal regiontelomeric repeats

Identifiers

PMID30002081
PMCPMC6116968
OpenAlexW2874314840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.