SynthesisHeart & lung : the journal of critical care
Effects of music intervention on inflammatory markers in critically ill and post-operative patients: A systematic review of the literature.
Synthesis in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06120660 (Effects of a Musical Intervention on Hormonal and Inflammatory Biomarkers in Mechanically Ventilated Critically Ill Patients), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of a Musical Intervention on Hormonal and Inflammatory Biomarkers in Mechanically Ventilated Critically Ill Patients
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Music intervention for sleep quality in critically ill and surgical patients: a meta-analysis.BMJ open · 2021Pooled it
- Personality Type Shapes Acute Anxiety Response to Music and Medicine Intervention During First Chemotherapy (PEGASUS-2).Applied psychophysiology and biofeedback · 2026Trial
- Slow-Tempo Music and Delirium/Coma-Free Days Among Older Adults Undergoing Mechanical Ventilation: A Randomized Clinical Trial.JAMA internal medicine · 2025Trial
- Refining a hybrid music therapy intervention for chronic obstructive pulmonary disease and heart failure: a single arm pilot study.BMC complementary medicine and therapies · 2025Trial
- The Effect of the Holy Quran Recitation on Inflammatory Markers in Hemodialysis Patients in Iran: A Randomized Clinical Trial.Journal of religion and health · 2024Trial
- Analysis of Preferred Music of Mechanically Ventilated Intensive Care Unit Patients Enrolled in a Randomized Controlled Trial.Journal of integrative and complementary medicine · 2022Trial
- Decreasing Delirium Through Music: A Randomized Pilot Trial.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2020Trial
- Effects of a Standardized Music Intervention on Propofol Requirements and Serum Interleukin-6 and Prolactin in Deeply Sedated Mechanically Ventilated Adults: A Prespecified Secondary Analysis of a Randomized Clinical Trial.Healthcare (Basel, Switzerland) · 2026Article
- Influence of Specific Acoustic Parameters on Responses in Growing Pigs: Towards a Precision Auditory Enrichment Strategy.Animals : an open access journal from MDPI · 2026Article
- Proposed Physiological and Neurobiological Mechanisms of Music's Effect, with a Focus on the Perioperative Period: Literature Evidence from Human, Canine and Feline Medicine.Veterinary sciences · 2025Review
- Music therapy as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model.Translational psychiatry · 2025Article
- The Effect of Music Therapy on Postoperative Pain and Agitation During Septorhinoplasty: A Blinded Clinical Trial.Health science reports · 2025Article
- Impact of Music Therapy on Neurodevelopment of Preterm Infants and Functional Improvement in Children with Neurological Deficits.Pediatric reports · 2025Review
- Music as a perioperative, non-pharmacological intervention in veterinary medicine. Establishing a feasible framework for music implementation and future perspectives with a focus on the perioperative period of dogs and cats.Frontiers in veterinary science · 2025Review
- A new therapy to alleviate the inflammatory injury of piglet intestine caused by short-distance transportation--music.PloS one · 2025Article
- Unraveling the Role of the Blood-Brain Barrier in the Pathophysiology of Depression: Recent Advances and Future Perspectives.Molecular neurobiology · 2024Review
- Music-based therapeutic interventions for medical school students with emotional regulation and mental health: a pre-post cohort study.Frontiers in psychology · 2024Article
- Effect of a music intervention on anxiety in adult critically ill patients: a multicenter randomized clinical trial.Journal of intensive care · 2023Article
- Music Interventions and Delirium in Adults: A Systematic Literature Review and Meta-Analysis.Brain sciences · 2022Review
- A Neurobiological Framework for the Therapeutic Potential of Music and Sound Interventions for Post-Traumatic Stress Symptoms in Critical Illness Survivors.International journal of environmental research and public health · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundMusic listening has been shown to reduce anxiety, stress, and patient tolerance of procedures. Music may also have beneficial effects on inflammatory biomarkers in intensive care and post-operative patients, but the quality of evidence is not clear.
objectivesWe conducted a systematic review to evaluate the effects of music on inflammatory biomarkers in intensive care, and post-operative patients.
methodsA comprehensive search of the literature was performed. After screening 1570 references, full text review of 26 studies was performed. Fourteen studies were selected for inclusion.
resultsSeven studies showed a significant decrease in cortisol levels, but the level of evidence was low. Three studies had low risk of methodological bias, while 11 studies had high risk of bias.
conclusionsMusic intervention may decrease cortisol levels, but other biomarkers remain unchanged. Given the low level of evidence, further research on music effects on inflammatory biomarkers is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.