Evidence map›Paper›PMID 30001714›Full record

ArticleBMC cancer2018

A pilot study to profile salivary angiogenic factors to detect head and neck cancers.

L van der Merwe, Y Wan, H J Cheong, C Perry, C Punyadeera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. An Exploratory Study Demonstrating That Salivary Cytokine Profiles Are Altered in Children With Small Area Thermal Injury.Journal of burn care & research : official publication of the American Burn Association · 2022
    Article
  3. Article
  4. Review
  5. The potential prognostic utility of salivary galectin-3 concentrations in heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

L van der MerweThe School of Biomedical Sciences, Institute of Health and Biomedical Innovations, Queensland University of Technology, 60 Musk Avenue, GPO Box 2434, Kelvin Grove, Brisbane, QLD, 4059, Australia.
Y WanThe School of Biomedical Sciences, Institute of Health and Biomedical Innovations, Queensland University of Technology, 60 Musk Avenue, GPO Box 2434, Kelvin Grove, Brisbane, QLD, 4059, Australia.
H J CheongThe School of Biomedical Sciences, Institute of Health and Biomedical Innovations, Queensland University of Technology, 60 Musk Avenue, GPO Box 2434, Kelvin Grove, Brisbane, QLD, 4059, Australia.
C PerryDepartment of Otolaryngology, Princess Alexandra Hospital, 199 Ipswich Road, Woolloongabba, Brisbane, QLD, 4102, Australia.
C PunyadeeraThe School of Biomedical Sciences, Institute of Health and Biomedical Innovations, Queensland University of Technology, 60 Musk Avenue, GPO Box 2434, Kelvin Grove, Brisbane, QLD, 4059, Australia. chamindie.punyadeera@qut.edu.au.ORCID http://orcid.org/0000-0003-3224-7350
Queensland University of Technology · AUPrincess Alexandra Hospital · AUTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly diagnosis of head and neck squamous cell carcinoma (HNSCCs) is an appealing way to increase survival rates in these patients as well as to improve quality of life post-surgery. Angiogenesis is a hallmark of tumor initiation and progression. We have investigated a panel of angiogenic factors in saliva samples collected from HNSCC patients and controls using the Bio-Plex ProT

methodsWe have identified a panel of five angiogenic proteins (sEGFR, HGF, sHER2, sIL-6Ra and PECAM-1) to be elevated in the saliva samples collected from HNSCC patients (n = 58) compared to a control cohort (n = 8 smokers and n = 30 non-smokers).

resultsHigh positive correlations were observed between the following sets of salivary proteins; sEGFR:sHER2, sEGFR:HGF, sEGFR:sIL-6Rα, sHER2:HGF and sHER2:sIL6Ra. A moderate positive correlation was seen between FGF-basic and sEGFR.

conclusionWe have shown that angiogenic factor levels in saliva can be used as a potential diagnostic biomarker panel in HNSCC.

Indexed as

AdultAgedAngiogenic ProteinsBiomarkers, TumorErb-b2 Receptor Tyrosine KinasesErbB ReceptorsFemaleHead and Neck NeoplasmsHepatocyte Growth FactorHumansMaleMiddle AgedPilot ProjectsPlatelet Endothelial Cell Adhesion Molecule-1Receptors, Interleukin-6SalivaAngiogenic ProteinsBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesErbB ReceptorsHepatocyte Growth FactorHGF protein, humanPlatelet Endothelial Cell Adhesion Molecule-1Receptors, Interleukin-6Vascular Endothelial Growth Factor AAngiogenesisHead and neck squamous cell carcinomaHuman papillomavirusSaliva

Identifiers

PMID30001714
PMCPMC6043960
OpenAlexW2883303286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.