Evidence map›Paper›PMID 30001512›Full record

ArticleNeuron2018

Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection.

William A Eimer, Deepak Kumar Vijaya Kumar, Nanda Kumar Navalpur Shanmugam, Alex S Rodriguez, Teryn Mitchell, Kevin J Washicosky, Bence György, Xandra O Breakefield, Rudolph E Tanzi, Robert D Moir

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 394 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
394citing papers in PubMed, 3 pooled it
42.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

394 citing papers in PubMed, 3 syntheses or guidelines pooled it, 659 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Interpreting Viral Associations in Neurodegenerative Diseases.International journal of molecular sciences · 2026
    Review
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  8. Article
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  17. The neuroimmune system and cognition.Nature immunology · 2026
    Review
  18. Article
  19. Article
  20. Article

334 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

William A EimerGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Deepak Kumar Vijaya KumarGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Nanda Kumar Navalpur ShanmugamGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Alex S RodriguezGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Teryn MitchellGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Kevin J WashicoskyGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Bence GyörgyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Xandra O BreakefieldDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Rudolph E TanziGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: tanzi@helix.mgh.harvard.edu.
Robert D MoirGenetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: moir@helix.mgh.harvard.edu.
Harvard University · US

Funding

The Abeta protein of Alzheimer's Disease is an antimicrobial peptideR01AI081990 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MOIR, ROBERT D · 2010 to 2014
$2.2M
A novel human 3D neural cell culture system for the characterization of AD genesRF1AG048080 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI KIM, DOO YEON, TANZI, RUDOLPH EMILE · 2014 to 2014
$2.1M
NIAID NIH HHS R01 AI081990NIA NIH HHS RF1 AG048080
6 · The paper itself

Abstract

Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects against fungal and bacterial infections. Fibrilization pathways mediate Aβ antimicrobial activities. Thus, infection can seed and dramatically accelerate β-amyloid deposition. Here, we show Aβ oligomers bind herpesvirus surface glycoproteins, accelerating β-amyloid deposition and leading to protective viral entrapment activity in 5XFAD mouse and 3D human neural cell culture infection models against neurotropic herpes simplex virus 1 (HSV1) and human herpesvirus 6A and B. Herpesviridae are linked to AD, but it has been unclear how viruses may induce β-amyloidosis in brain. These data support the notion that Aβ might play a protective role in CNS innate immunity, and suggest an AD etiological mechanism in which herpesviridae infection may directly promote Aβ amyloidosis.

Indexed as

HerpesviridaeAlzheimer DiseaseAmyloid beta-PeptidesAmyloidosisAnimalsBrainCells, CulturedDisease Models, AnimalEncephalitis, Herpes SimplexEncephalitis, ViralHerpesvirus 1, HumanHerpesvirus 6, HumanHumansMiceMice, TransgenicNeurofibrillary TanglesAmyloid beta-PeptidesAlzheimer’s diseaseamyloid-βantimicrobial peptideherpes simplex virus 1herpesviridaeherpesvirus glycoproteinhuman herpesvirus 6infectionoligomersβ-amyloid peptide

Identifiers

PMID30001512
PMCPMC6075814
OpenAlexW2805303487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.