Evidence map›Paper›PMID 30001435›Full record

ArticlePLoS pathogens2018

Illuminating pathogen-host intimacy through optogenetics.

Ruben Dario Arroyo-Olarte, Laura Thurow, Vera Kozjak-Pavlovic, Nishith Gupta

Abstract read
In one paragraph

Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Light Up the COVID-19.Journal of medical signals and sensors
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ruben Dario Arroyo-OlarteDepartment of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.
Laura ThurowDepartment of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.ORCID 0000-0001-5621-5391
Vera Kozjak-PavlovicDepartment of Microbiology, Biocenter, Julius Maximilian University, Würzburg, Germany.ORCID 0000-0001-9658-7018
Nishith GuptaDepartment of Molecular Parasitology, Faculty of Life Sciences, Humboldt University, Berlin, Germany.ORCID 0000-0003-1452-5126

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The birth and subsequent evolution of optogenetics has resulted in an unprecedented advancement in our understanding of the brain. Its outstanding success does usher wider applications; however, the tool remains still largely relegated to neuroscience. Here, we introduce selected aspects of optogenetics with potential applications in infection biology that will not only answer long-standing questions about intracellular pathogens (parasites, bacteria, viruses) but also broaden the dimension of current research in entwined models. In this essay, we illustrate how a judicious integration of optogenetics with routine methods can illuminate the host-pathogen interactions in a way that has not been feasible otherwise.

Indexed as

AnimalsHost-Pathogen InteractionsHumansOptogenetics

Identifiers

PMID30001435
PMCPMC6042787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.