Evidence map›Paper›PMID 30001355›Full record

Observational studyPloS one2018

Characteristics, treatment and quality of life of stable coronary artery disease patients with or without angina: Insights from the START study.

Leonardo De Luca, Pier Luigi Temporelli, Donata Lucci, Furio Colivicchi, Paolo Calabrò, Carmine Riccio, Antonio Amico, Franco Mascia, Emanuele Proia, Andrea Di Lenarda and 2 more

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03796741 (STable Coronary Artery Diseases RegisTry), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03796741 completednot on this map

STable Coronary Artery Diseases RegisTry

TypeobservationalSponsorHeart Care FoundationRan2016 to 2018Enrolled5,070ConditionsChronic Ischemic Heart DiseaseArmsData collection on Stable Ischemic heart disease
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Cost-Effectiveness and Budget Impact Analysis of Radiofrequency Renal Denervation for Uncontrolled and Resistant Hypertension in Italy.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Article
  2. Article
  3. Letter: Applicability of ISCHEMIA in real-world practice: where to START?EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Leonardo De LucaDivision of Cardiology, S. Giovanni Evangelista Hospital, Tivoli (Roma), Italy.ORCID 0000-0002-8552-1272
Pier Luigi TemporelliDivision of Cardiology, Istituti Clinici Scientifici Maugeri, IRCCS, Veruno (Novara), Italy.
Donata LucciANMCO Research Center, Firenze, Italy.ORCID 0000-0002-8614-785X
Furio ColivicchiDivision of Cardiology, S. Filippo Neri Hospital, Roma, Italy.
Paolo CalabròDepartment of Cardiology, Azienda Ospedaliera Sant'Anna e San Sebastiano, Caserta, Italy.
Carmine RiccioDepartment of Cardiology, Azienda Ospedaliera Sant'Anna e San Sebastiano, Caserta, Italy.
Antonio AmicoDivision of Cardiology, S. Giuseppe Hospital, Copertino (Lecce), Italy.
Franco MasciaDepartment of Cardiology, Azienda Ospedaliera Sant'Anna e San Sebastiano, Caserta, Italy.
Emanuele ProiaDivision of Cardiology Ave Gratia Plena Hospital, Piedimonte Matese (Caserta) Italy.
Andrea Di LenardaCardiology, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy.
Michele Massimo GuliziaDivision of Cardiology, Garibaldi-Nesima Hospital, Catania, Italy.
START Investigators
Ospedale Sant'Anna · ITAssociazione Nazionale Medici Cardiologi Ospedalieri · ITAzienda Sanitaria Universitaria Integrata di Trieste · ITIstituti Clinici Scientifici Maugeri · ITOspedale Garibaldi · ITOspedale Maggiore · ITOspedale San Filippo Neri · ITOspedale San Giuseppe · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data on contemporary management patterns of angina in patients with stable coronary artery disease (CAD) are scarce. We sought to describe the current presentation, management, and quality of life of stable CAD patients with or without angina, using the data from the START (STable Coronary Artery Diseases RegisTry) study. START was a prospective, observational, nationwide study aimed to evaluate the presentation, management, treatment and quality of life of stable CAD presenting to cardiologists during outpatient visits or discharged from cardiology wards. Among the 5070 consecutive stable CAD patients enrolled in 183 participating centers over a 3-month period, 3714 (73.2%) had no angina and 1356 (26.8%) presented with angina. Patients with angina underwent more frequently coronary angiography (92.7% vs 84.9%; p<0.0001) and other diagnostic imaging procedures compared to those without angina. In addition, patients with angina received more frequently different combinations of first line therapies and angina relief drugs compared to patients without angina. The quality of life, assessed with the EQ 5D-5L questionnaire, did not differ between the two groups, with the exception of the 'pain or worry' domain that was higher in patients with compared to those without angina (p<0.0001). Current management and treatment of stable CAD patients with angina is still suboptimal and different compared to those without angina. Our findings highlight the need for disseminating best-practice patterns and improving guidelines adherence for the management of angina even among cardiologists.

Indexed as

Quality of LifeAgedAged, 80 and overAngina PectorisCoronary Artery DiseaseFemaleHumansMaleMiddle Aged

Identifiers

PMID30001355
PMCPMC6042700
OpenAlexW2866225680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.