ArticlePloS one2018
In vivo 13C-MRI using SAMBADENA.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 49 citations in OpenAlex.
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- Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules.Angewandte Chemie (International ed. in English) · 2026Article
- Ultra-low fieldCommunications chemistry · 2026Article
- Upscaling the Hyperpolarization Sample Volume of an Automated Hydrogenative Parahydrogen-Induced Polarizer.ACS measurement science au · 2025Article
- Novel non‑metal‑based contrast agents for MR imaging: Emerging approaches and clinical perspectives (Review).International journal of oncology · 2025Review
- Overcoming the Challenges of Hyperpolarizing Substrates with Parahydrogen-Induced Polarization in an MRI System.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications.Analysis & sensing · 2025Article
- Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer.Communications chemistry · 2024Article
- Spying on parahydrogen-induced polarization transfer using a half-tesla benchtop MRI and hyperpolarized imaging enabled by automation.Nature communications · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Metabolic Tumor Imaging with Rapidly Signal-Enhanced 1-Chemphyschem : a European journal of chemical physics and physical chemistry · 2023Article
- Recent advances in the application of parahydrogen in catalysis and biochemistry.RSC advances · 2022Review
- Quasi-continuous production of highly hyperpolarized carbon-13 contrast agents every 15 seconds within an MRI system.Communications chemistry · 2022Article
- Frequency-Selective Manipulations of Spins allow Effective and Robust Transfer of Spin Order from Parahydrogen to Heteronuclei in Weakly-Coupled Spin Systems.Chemphyschem : a European journal of chemical physics and physical chemistry · 2022Article
- Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques.Analytical chemistry · 2022Article
- HyperpolarizedChemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- PHIP hyperpolarized [1-Scientific reports · 2021Article
- Biomedical Applications of the Dynamic Nuclear Polarization and Parahydrogen Induced Polarization Techniques for HyperpolarizedMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2021Review
- Hydrogenative-PHIP polarized metabolites for biological studies.Magma (New York, N.Y.) · 2021Review
- High fieldPhysical chemistry chemical physics : PCCP · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic Resonance Imaging (MRI) is a powerful imaging tool but suffers from a low sensitivity that severely limits its use for detecting metabolism in vivo. Hyperpolarization (HP) methods have demonstrated MRI signal enhancement by several orders of magnitude, enabling the detection of metabolism with a sensitivity that was hitherto inaccessible. While it holds great promise, HP is typically relatively slow (hours), expensive (million $, €) and requires a dedicated device ("polarizer"). Recently, we introduced a new method that creates HP tracers without an external polarizer but within the MR-system itself based on parahydrogen induced polarization (PHIP): Synthesis Amid the Magnet Bore Allows Dramatically Enhanced Nuclear Alignment (SAMBADENA). To date, this method is the simplest and least cost-intensive method for hyperpolarized 13C-MRI. HP of P13C > 20% was demonstrated for 5mM tracer solutions previously. Here, we present a setup and procedure that enabled the first in vivo application of SAMBADENA: Within seconds, a hyperpolarized angiography tracer was produced and injected into an adult mouse. Subsequently, fast 13C-MRI was acquired which exhibited the vena cava, aorta and femoral arteries of the rodent. This first SAMBADENA in vivo 13C-angiography demonstrates the potential of the method as a fast, simple, low-cost alternative to produce HP-tracers to unlock the vast but hidden powers of MRI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.