ArticlePLoS biology2018
Molecular mechanism of the tree shrew's insensitivity to spiciness.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMInternational journal for parasitology. Drugs and drug resistance · 2026Article
- Capsaicin responses in Drosophila: Exploring the possibility of establishing a new Non-TRPV1 model.Biochemistry and biophysics reports · 2026Review
- Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A Superefficient Ochratoxin A Hydrolase with Promising Potential for Industrial Applications.Applied and environmental microbiology · 2022Article
- Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1 channels.British journal of pharmacology · 2021Article
- A novel tree shrew model of pulmonary fibrosis.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Target switch of centipede toxins for antagonistic switch.Science advances · 2020Article
- A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds.The Journal of biological chemistry · 2020Article
- A single TRPV1 amino acid controls species sensitivity to capsaicin.Scientific reports · 2020Article
- TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh.Nature communications · 2020Article
- The Mysteries of Capsaicin-Sensitive Afferents.Frontiers in physiology · 2020Review
- Diverse sensitivities of TRPA1 from different mosquito species to thermal and chemical stimuli.Scientific reports · 2019Article
- Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers.British journal of pharmacology · 2019Article
- Molecular basis for heat desensitization of TRPV1 ion channels.Nature communications · 2019Article
- Centipede KCNQ Inhibitor SsTx Also Targets KToxins · 2019Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spicy foods elicit a pungent or hot and painful sensation that repels almost all mammals. Here, we observe that the tree shrew (Tupaia belangeri chinensis), which possesses a close relationship with primates and can directly and actively consume spicy plants. Our genomic and functional analyses reveal that a single point mutation in the tree shrew's transient receptor potential vanilloid type-1 (TRPV1) ion channel (tsV1) lowers its sensitivity to capsaicinoids, which enables the unique feeding behavior of tree shrews with regards to pungent plants. We show that strong selection for this residue in tsV1 might be driven by Piper boehmeriaefolium, a spicy plant that geographically overlaps with the tree shrew and produces Cap2, a capsaicin analog, in abundance. We propose that the mutation in tsV1 is a part of evolutionary adaptation that enables the tree shrew to tolerate pungency, thus widening the range of its diet for better survival.
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