Evidence map›Paper›PMID 30001275›Full record

ReviewExercise and sport sciences reviews2018

Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle.

Andrew R Coggan, Linda R Peterson

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Exercise and sport sciences reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 50 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 8 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05720013 nacompletednot on this mapstarted 2023, after this paper: background citation

Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke

TypeinterventionalSponsorIndiana UniversityRan2023 to 2023Enrolled22ConditionsStroke, CVAArmsBeetroot Juice supplement, Placebo supplement
NCT06660784 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Mechanism of Nitric Oxide on Ventilator-induced Diaphragm Dysfunction with Extracorporeal Membrane Lung Assistance

TypeobservationalSponsorZhongnan HospitalRan2024 to 2025Enrolled80ConditionsTracheal Intubation, Extracorporeal Membrane Oxygenation, Nitric Oxide, Ventilator-induced Diaphragmatic DysfunctionArmsNitric Oxide
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 8 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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  5. The Effects of Dietary Nitrate Supplementation on Explosive Exercise Performance: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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  11. Dietary nitrate and muscle contractile function in women: effect of menstrual cycle phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2026
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  20. Dose-Response Effect of Dietary Nitrate on Muscle Contractility and Blood Pressure in Older Subjects: A Pilot Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Andrew R CogganDepartments of Kinesiology and.
Linda R PetersonMedicine and.
International College of Applied Kinesiology-USA · USWashington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
THE INORGANIC NITRATE FOR EXERCISE IN HEART FAILURE (INIX-HF) TRIALR34HL138253 · NHLBI · WASHINGTON UNIVERSITY · PI COGGAN, ANDREW R, PETERSON, LINDA RUTH · 2017 to 2019
$701k
NCATS NIH HHS UL1 TR002345NHLBI NIH HHS R34 HL138253NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway, which together increase the free intracellular Ca concentration along with the Ca sensitivity of the myofilaments themselves.

Indexed as

DietMuscle ContractionAnimalsCalciumCyclic GMPCyclic GMP-Dependent Protein KinasesHumansMuscle, SkeletalNitratesNitric OxideRyanodine Receptor Calcium Release ChannelSignal TransductionCalciumCyclic GMPCyclic GMP-Dependent Protein KinasesNitratesNitric OxideRyanodine Receptor Calcium Release Channel

Identifiers

PMID30001275
PMCPMC6138552
OpenAlexW2883886248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.